Interface dermatitis

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Synonym(s)

lichenoid dermatitis

Definition
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Characteristic histological pattern of diffuse superficial dermatitis detectable in etiopathogenetically different inflammatory dermatoses.

The interface dermatitis is characterized by an epitheliotropic, lymphocytic infiltrate which leads to chronic, vacuolar damage of the basal keratinocytes (and melanocytes) at the epidermis, with signs of apoptosis and its histomorphologically detectable consequences.

The term "lichenoid dermatitis" is also used synonymously with the term "interface dermatitis". Terminologically this refers to the lichen planus and is to be understood as a subgroup of interface dermatitis.

Classification
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Diseases whose histological substrate is characterized by interface dermatitis (varies according to El Shabrawi-Caelen and Soyer):

Histology
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The signs of apoptosis of keratinocytes are described as "dyskeratotic" or "single cell necrosis". Eosinophilic corpuscles with little structure remain at the dermo-epidermal junction zone even as:

  • cytoid corpuscles
  • Civatte-bodies
  • hyaline bodies
  • Colloidal body

is called.

Literature
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  1. El Shabrawi-Caelen L, Soyer H-P (2003) Inflammatory dermatoses of the dermoepidermal junction (interface dermatitis). In: Histopathology of the skin. Kerl H et al (Ed.) Springer Verlag, Berlin Heidelberg New York, S. 117

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Last updated on: 29.10.2020