Poikiloderma (overview) L81.89

Author: Prof. Dr. med. Peter Altmeyer

All authors of this article

Last updated on: 16.04.2023

Dieser Artikel auf Deutsch


congenital poikiloderma; Congenital poikiloderma; Poikilodermia acquired

This section has been translated automatically.

Poikiloderma (poikilos = mottled, marbled) refers to clinico-morphologically defined, etiologically distinct, congenital or acquired, variegated clinical pictures with circumscritic or diffuse atrophies, small-spot to reticular hyper- and depigmentation, telangiectasias, and erythema. Poikiloderma can occur in genetic, inflammatory, and neoplastic disorders.

The term "poikiloderma" also includes clinical pictures which can be counted among the so-called pre-aging syndromes.

This section has been translated automatically.

According to origin or association with syndromes one distinguishes:

Congenital (primary) poikiloderma (classification in a narrower sense, poikiloderma as a dermatological-clinical signature is indicative of an underlying polyorganic syndrome).

Poikiloderma in the context of other congenital syndromes:

Symptomatic (secondary) poikiloderma (in the context of chronic inflammatory or neoplastic underlying diseases):

This section has been translated automatically.

Due to the various causes, the histology of poikiloderma can be very variable. Common to all forms is an atrophic epidermis with striated rectal ridges, mild hyperkeratosis, pigment incontinence with melanophages in the papillary body and telangiectasia. Occasionally, vacuolization of the junctional zone with lymphocytes and dyskeratosis is detectable.

This section has been translated automatically.

  1. Vogl A et al (2005) Skin and alcohol. J Dtsch Dermatol Ges 3: 788-790


Please ask your physician for a reliable diagnosis. This website is only meant as a reference.


Last updated on: 16.04.2023