Synonym(s)
congenital development malformation; Dowling Syndrome; Thomson syndrome type verrucosus; Type verrucosus of Thomson syndrome
HistoryThis section has been translated automatically.
Dowling, 1936; Greither, 1958
DefinitionThis section has been translated automatically.
Congenital poikiloderma with hyperkeratosis, considered by some authors to be a special form of Thomson's syndrome. There is overlap with Kindler syndrome.
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EtiopathogenesisThis section has been translated automatically.
Probably autosomal recessive inheritance.
ManifestationThis section has been translated automatically.
Poikiloderma: Between 6 and 12 months of age. Hyperkeratoses: Between 7 and 10 years of age.
Clinical featuresThis section has been translated automatically.
Poikiloderma, especially in the face, warty hyperkeratosis over bony prominences. Proportionate dwarfism. Associated symptoms: palmoplantar keratoses.
General therapyThis section has been translated automatically.
Regular skin check-ups to rule out malignant neoplasia.
External therapyThis section has been translated automatically.
Internal therapyThis section has been translated automatically.
Trial with acitretin (neotigason) dosage 0.5-1.0 mg/kg bw/day over a longer period of time as tumor prophylaxis.
Progression/forecastThis section has been translated automatically.
Occurrence of spinocellular carcinomas.
Note(s)This section has been translated automatically.
There have been no further messages since 1981!
LiteratureThis section has been translated automatically.
- Dowling GB (1936) Congenital developmental malformation. Proc R Soc Med 29: 1633-1634
- Greither A (1958) On hereditary dysplasia of the skin associated with keratoses and pigment disorders. Dermatologist 9: 364-369
- Pickenacker A et al (1998) Congenital poikiloderma with verruciform hyperkeratoses (Dowling type). dermatologist 49: 586-590
- Schrallhammer K et al (1988) Congenital poikiloderma with warty hyperkeratoses. Dermatologist 39: 143-148
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Incoming links (9)
Congenital development malformation; Dowling syndrome; Salicylic acid ointment 1/2/3/5/10 or 20% (nrf 11.43.); Salicylic acid ointment (w/o); Thomson syndrome; Thomson syndrome, type verrucosus; Tretinoin cream hydrophilic 0.025/0.05 or 0.1% (nrf 11.101.); Urea 10%/lactic acid 5% cream (nfa) (o/w); Urea 10%/salt 3% ointment (w/o);Outgoing links (14)
Acitretin; Hyperkeratoses; Kindler syndrome; Lactic acid; Palmoplantar keratoses (overview); Poikiloderma (overview); Salicylic acid ointment 1/2/3/5/10 or 20% (nrf 11.43.); Salicylic acid ointment (w/o); Squamous cell carcinoma of the skin; Thomson syndrome; ... Show allDisclaimer
Please ask your physician for a reliable diagnosis. This website is only meant as a reference.
Prof. Dr. med. Peter Altmeyer