Foscarnet

• CMV-Retinitis: Initial 2 times/day 90 mg/kg bw/day i.v. in 500 ml NaCl-solution 0,9% (let infusion run for at least 2 hours) over 2-3 weeks, maintenance therapy: 90 mg/kg bw i.v. 5 days/week for life, if necessary alternating with ganciclovir for 14 days.
• Aciclovir-resistant infections caused by Herpes simplex or Varizella zoster in AIDS patients: 90 mg/kg bw/day i.v. for 7-10 days.

Notice! Never infuse undiluted into a peripheral vein(thrombophlebitis!) To avoid hypocalcaemia, infuse one ampoule of 10% calcium solution in 100 ml 5% glucose immediately before the foscarnet infusion. After the foscarnet infusion, add 500 ml 5% glucose. Always ensure good hydration of the patient. Check creatinine, calcium, potassium and Hb at least 2 times/week. Adjust the dose if creatinine levels rise!

• For topical application: paragroup allergy, allergic skin reactions, skin irritation.
• In i.v. application: renal dysfunction to rare renal failure requiring dialysis, electrolyte shifts (hypocalcemia with cramps in the hands, paw position of the hands, positive Trousseau phenomenon, hypokalemia), nausea, headache, BB changes (Hb drop > 20%), epileptic seizures, ulcerations in the glans penis area.

Remember! Male patients should not conceive children under foscarnet therapy, consistent contraception during therapy and until 6 months after the end of therapy!

Remember! Never use a condom urinoir during foscarnet therapy! inform male patients about the need for careful hygiene after each micturition!

Essential interactions of foscarnet in systemic application