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Endemic in tropics and subtropics (even in highly urbanised areas!) outside Europe (South East Asia, South Pacific, Africa, Central and South America, Caribbean).
About 2-3 billion people worldwide live in endemic areas. Incidence (worldwide): Approx. 50 million infections per year, of which approx. 500,000 cases of dengue haemorrhagic fever (DHF) and 20,000 deaths (mainly children). The considerable global tendency to spread is based on the worldwide decline in vector control for decades, the increase in urban breeding grounds in conjunction with increasing littering in the poor quarters of the tropics, and increased international migration and travel.
Nationwide about 2,000 illnesses/year are reported, especially among holiday travellers (Thailand!) or migrants.
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All 4 serotypes cause identical disease symptoms. Classical dengue fever begins after an incubation period of 5-8 days with high fever, severe headache, bone pain ("bone-breaking fever"), swelling of joints. Prior to the convalescence phase, a morbilli- or scarlatiniform exanthema develops; often eye involvement, lymph node swelling. Afterwards, the patient walks for a long time in a peculiar way (dengue = ornamental).
Dengue haemorrhagic fever (DHF) (see haemorrhagic fever below) has a two-phase course: dengue fever followed by brief remission (phase 1), followed by sudden deterioration with bleeding in the skin and mucous membranes (phase 2).
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Symptomatic, according to WHO guidelines. Cave! Aspirin in hemorrhagic diathesis should be avoided.
Monitoring of vital functions, sufficient fluid intake, in case of disseminated coagulopathy possibly heparin therapy.
Skin changes symptomatic with cooling lotions.
Haemorrhagic forms require immediate intensive medical treatment.
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Remember! Notification obligation in case of pathogen detection or hemorrhagic course of disease!
LiteratureThis section has been translated automatically.
- Aviles G et al (2003) Complete coding sequences of dengue-1 viruses from Paraguay and Argentina. Virus Res 98: 75-82
- Hlastead SB, Deen JL (2002) The future if dendue vaccine. Lancet 360: 1100-1101
- de Oliveira Poersch C et al (2005) Dengue virus infections: comparison of methods for diagnosing the acute disease. J Clin Virol 32: 272-277
- DeRoeck D et al (2003) Policymakers' views on dengue fever/dengue haemorrhagic fever and the need for dengue vaccines in four southeast Asian countries. Vaccines 22: 121-129
- Kay B, Vu SN (2005) New strategy against Aedes aegypti in Vietnam. Lancet. 365: 613-617
- Rush B (1789) An account of the bilious remitting fever, as it appeared in Philadelphia in the summer and autumn in the year 1780. in: Rush B (ed) Medical inquiries and observations. Pritchard & Hall, Philadelphia, S. 89-100
- Sideridis K et al (2003) Dengue fever: diagnostic importance of a camelback fever pattern. Heart Lung 32: 414-418
- Wichmann O et al (2005) Dengue antibody prevalence in German travelers. Emerg Infect Dis 11: 762-765
Incoming links (12)Classification of viruses; Dandy fever; Flaviviridae; Hepatitis c virus; O'nyong-nyong; Oropouche fever; Pappataci fever; Rift valley fever; Ross river virus infection; Vegf; ... Show all
Outgoing links (1)Fever, hemorrhagic;
Please ask your physician for a reliable diagnosis. This website is only meant as a reference.