O'nyong-nyong A92.1

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Synonym(s)

Joint Crusher Virus Infection; ONN virus infection; O'nyong-nyong fever

Definition
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Infectious disease transmitted by mosquitoes with the O'nyong-nyong virus (endemic arbovirosis).

Pathogen
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  • O'nyong-nyong virus, genus Alphavirus, family Togaviridae, belongs to the Semliki Forest complex.
  • Counted among the arboviroses. Transmission by Anopheles mosquitoes; in the sylvatic cycle (virus was found in sloths), Aedes and Culex mosquitoes.

Occurrence/Epidemiology
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  • Endemo-epidemic, currently only sporadically occurring.
  • Hereditary description in Uganda 1959-1962 during a major epidemic that affected about 2 million people, subsequently spreading to Kenya, Tanzania and Zambia and even to the whole of Equatorial and East Africa.

Clinical features
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Incubation period 4-8 days. Symptoms are chills, fever (not regular) headache and severe symmetrical joint pain of the large joints. On day 4 maculopapular exanthema (spreading from the neck to the trunk) ( viral exanthema), lymphadenopathy. Only slow regeneration and recovery. There is long lasting immunity.

Diagnosis
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  • Serum antibody
  • Virus cultivation
  • Neutralisation test
  • Leukocytopenia
  • reactivated lymphocytes.

Differential diagnosis
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Chikungunya; dengue fever; other alpha and flavivi roses; rheumatoid arthritis, autoimmune diseases.

Therapy
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Symptomatic with non-steroidal anti-inflammatory drugs.

Prophylaxis
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Mosquito protection and mosquito control.

Note(s)
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The synonym "joint breaker" virus infection is borrowed from the Bantu (Ganda) language.

Incoming links (1)

Ross river virus infection;

Disclaimer

Please ask your physician for a reliable diagnosis. This website is only meant as a reference.

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Last updated on: 29.10.2020