Atovaquon

Definition
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Antiprotozoal agent.

Half-life
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> 50 h

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Indication
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Pneumocystis carinii pneumonia or toxoplasmosis in AIDS patients(replacement preparation especially for glucose-6-phosphate dehydrogenase deficiency).

Dosage and method of use
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3 times 750 mg/day p.o. during meals.

Undesirable effects
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Nausea, diarrhoea, allergic reactions, headaches, vomiting, insomnia, increase in transaminases and amylases, anemia.

Interactions
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See Table 1.

Contraindication
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Pregnancy, nursing.

Preparations
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Wellvone

Tables
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Essential interactions of Atovaquon

Aciclovir	Atovaquon plasma mirror ↓
Benzodiazepines	Atovaquon plasma mirror ↓
Cephalosporins	Atovaquon plasma mirror ↓
Fluconazole	Atovaquon plasma mirror ↓
Metoclopramide	Atovaquon plasma mirror ↓
Opiates	Atovaquon plasma mirror ↓
Paracetamol	Atovaquon plasma mirror ↓
Prednisolone	Atovaquon plasma mirror ↑
Rifampicin	Atovaquon plasma mirror ↓ by 50% ↓
Zidovudine (AZT)	Atovaquon ↑ Plasma level by 35%