Atovaquone/proguanil

Author: Prof. Dr. med. Peter Altmeyer

Our authors

Last updated on: 29.10.2020

Dieser Artikel auf Deutsch

Definition
This section has been translated automatically.

Active ingredient combination for malaria therapy from Atovaquon and Proguanil.

Spectrum of action
This section has been translated automatically.

Effective against blood and hepatic schizons of P. falciparum (Malaria tropica).

Indication
This section has been translated automatically.

Prophylaxis of malaria tropica and treatment of acute, uncomplicated malaria tropica, especially if P. falciparum may be resistant to other antimalarial drugs.

Pregnancy/nursing period
This section has been translated automatically.

Strict indication (insufficient data available).

Dosage and method of use
This section has been translated automatically.

Malarone (250 mg atovaquone/100 mg proguanil per tbl):
  • Adults, children > 40 kg bw: 4 film sheets as ED on 3 consecutive days.
  • Children: 11-20 kg bw: 1 tablet/day on 3 consecutive days; 21-30 kg bw: 2 tablets as ED on 3 consecutive days; 31-40 kg bw: 3 tablets as ED on 3 consecutive days.
Prophylaxis: Start 1 tbl. p.o. 1-2 days before entering the endemic area, continue during the stay and 7 days after leaving the endemic area.

Remember! In case of vomiting as ADR after taking medication, the dose should be taken again (especially for malaria prophylaxis)!

Undesirable effects
This section has been translated automatically.

Occasionally headache, abdominal pain, diarrhea, fever, nausea, vomiting, pruritus.

Interactions
This section has been translated automatically.

Reduction of atovaquone plasma levels with simultaneous treatment with metoclopramide, tetracyline, rifampicin, rifabutin.

Contraindication
This section has been translated automatically.

Malaria prophylaxis in patients with severely impaired kidney function (creatinine clearance < 30 ml/min).

Preparations
This section has been translated automatically.

Malarone, Malarone Junior

Authors

Last updated on: 29.10.2020