Antihistamines, h2-antagonists

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 18.12.2020

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Synonym(s)

H2 antagonists; H2-receptor blockers

Definition
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Drugs that block H2-receptors of the document cells in the stomach and lead to the healing of ventricular and duodenal ulcers by reducing acid secretion.

Indication
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H2-antagonists are used in dermatology as concomitant medication in systemic glucocorticoid, immunosuppressive or cytostatic therapy.

Limited indication
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Pregnancy, nursing, renal failure.

Dosage and method of use
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S. Tab.

Undesirable effects
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Allergic reactions, CNS disorders, dizziness, blood formation disorders, eosinophilia, bronchospasms, gastrointestinal disorders.

Interactions
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S. Tab.

Contraindication
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Paragroup allergy (applies only to suspensions), sorbitol intolerance (applies only to suspensions), children and adolescents < 16 years, porphyria, severe hepatic dysfunction, anuria .

Tables
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Essential interactions of H2-antagonists

Acenocoumarol

Bleeding tendency ↑

Barbiturates

Barbiturate levels ↑

Captopril

Neuropathy ↑

Carbamazepine

Carbamazepine levels ↑

Carmustin

Carmustine toxicity ↑, myelosuppression ↑

Chlordiazepoxide

Chlordiazepoxide levels ↑

Chlorpromazine

Tiredness ↑

Clomethiazole

Clomethiazole levels ↑

Digitoxin

Digitoxin toxicity ↑

Diltiazem

Diltiazem toxicity ↑

Iron

Iron Mirrors ↓

Erythromycin

Erythromycin toxicity ↑, hearing impairment ↑

Halofrantin

Halofrantin bioavailability ↓, avoid combination

Hydromorphone

Hydromorphone mirrors ↑

Isradipin

Isradipine levels ↑, RR drop, halve the Isradipine dose

Itraconazole

Itraconazole level ↓, intake 2 hours apart

Ketoconazole

Ketoconazole levels ↓

Labetalol

Labetalol mirrors ↑

Levomethadone

Levomethadone levels ↑

Lidocaine IV.

Lidocaine levels ↑, halve lidocaine dose

Magnesium Antacids

H2-antagonist mirror ↓, to be taken 2 hours apart

Mebendazole

Mebendazole level ↑

Metformin

Metformin-Spiegel↑, Lactate Acidosis

Metoclopramide

H2-antagonist mirror ↓, to be taken 2 hours apart

Metoprolol

Metoprolol levels ↑, bradycardia

Nifedipine

Nifedipine levels ↑, RR waste

Nicotine abuse

H2-antagonist effect ↓

Opioid analgesics

Opioid toxicity ↑, seizures, confusion, respiratory arrest

Phenytoin

Phenytoin levels ↑

Procainamide

Procainamide level ↑, excitation conduction disorders

Propanolol

Propanolol levels ↑, bradycardia

Rifabutin

Rifabutin levels ↑

Sulfonylurea antidiabetics

antidiabetic effect ↑

Terbinafine

Terbinafine levels ↑

Tetracyclines

Tetracycline effect ↓

Theophylline

Theophylline levels ↑

Valproic acid

Valproic acid level ↑

Warfarin

Bleeding tendency ↑

Zidovudine

Zidovudine toxicity ↑


Overview of the most important H2-antagonists and their dosage

Active substance

Dosage

Preparation

Cimetidine

400 mg/day p.o.

Tagamet

Famotidine

20 mg/day p.o. in the evening

Pepdul

Nizatadine

200 mg/day p.o. in the evening

Nizax

Ranitidine

300 mg/day p.o. in the evening

Sostril, Zantic

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Last updated on: 18.12.2020