Valerian root + hop cone

Fixed combination of Valerianae radix and Lupuli flos, hop cones, which has the status of a recommendation according to Commission E and is therefore designated as a model.

HMPC monograph: Correction for the combination of both monosubstances dated 06.06.2011:

Well-established use: Sleep disorders

Valerian root drug-extract ratio (DEV) 4 to 8:1, extractant: 45 to 51 percent (m/m) methanol plus hop cones DEV 3 to 10:1, extractant: 40 to 51 percent (m/m) methanol in a fixed combination of 187 mg/28 mg to 500 mg/65 mg dry extract of valerian root and hop cones respectively.

Valerian root DEV 4 to 7:1, extractant: 70 percent (V/V) ethanol plus hop cones DEV 4 to 8:1, extractant: 40 percent (V/V) methanol in a fixed combination of 200 mg/45 mg to 350 mg/70 mg dry extract of valerian root and hop cones respectively

and Traditional-use: Mild nervous restlessness, difficulty falling asleep

1:1 mixture of valerian root and hop cones, DEV 1:6.3, extractant: 40 percent (V/V) ethanol, single dose: 20 ml

1:1 mixture of valerian root tincture (DEV 1:10, 53 percent (m/m) ethanol) and hop cone fluid extract (DEV 1:2.2, 53 percent (m/m) ethanol, 40 or 75 drops in half a glass of water

see also under trade names

The fixed combination of:

• Valerianaradix(valerian root)
• Humulus lupulus (hop cone)

has a sleep-inducing and sedative effect.

Difficulty falling asleep / nervous restlessness.

It should be taken for four weeks.

In a fixed combination of valerian root and hop cones, both constituents must be present as a single drug with 50 to 75 % of their daily dose each. The combination of these drugs is mostly used in the form of infusions and other preparations for ingestion.

Gastrointestinal disorders: Nausea, abdominal cramps and abdominal pain. Cave: from 20 g valerian root possibly fatigue, abdominal cramps, chest tightness, drowsiness, hand tremor and mydriasis, cave driving and operating machinery.

Children and adolescents under 12 years of age, pregnancy and breastfeeding.

There are no known interactions with other substances.

Difficulty falling asleep: e.g. ^{Valerian-Dispert®} Night, ^Ardeysedon® Night, Alluna® Film-coated tablets 1 tablet 30-60 minutes before going to sleep.

Nervous restlessness: e.g. ^Ardeysedon® 1-3 x 2 tablets, Abbey Valerian+Hop Dragees for calming 1-3 x 1 tablet, Alluna® film-coated tablets 1-3 x 1 tablet.

1. Schilcher H (2016) In: Leitfaden Phytotherapie, Urban & Fischer Verlag Munich, p. 358 f.
2. Wiesenauer M (2008) PhytoPraxis. Springer Medizin Verlag Heidelberg
3. https://www.pharmazeutische-zeitung.de/baldrianwurzel-und-hopfenzapfen/