Valerianae radix

Rootstock and root of valerian, see also valerian root.

Quality is defined in the European Pharmacopoeia (Ph. Eur.):

HMPC - Monograph: well-established use as dry extract (DEV 3-7,4:1, extractant ethanol 40-70 %): mild nervous tension and insomnia. Also well-established use in combinations of valerian root and hop cones: insomnia. Additionally traditional-use: valerian root cut drug and other dry extracts, liquid extracts, valerian tincture, valerian fresh plant juice and valerian essential oil: mild stress-related symptoms, sleep aid
ESCOP monograph: mild nervous tension and/or sleep disorders
Commission e-monograph: restlessness, nervous sleep disorders

Empirical medicine: nervous stomach cramps, colic and uterine spasms. Dropsy and hysterical attacks. Formerly also used as a vermifuge.

In combination with hop cones in the form of dry extracts also positive effects.

HMPC monograph: well-established use: improvement of insomnia

ESCOP monograph: restlessness, nervous sleep disorders

Commission E monograph: restlessness, nervous sleep disorders

Empirical medicine: nervous stomach cramps, colic and uterine spasms.

In terms of quality, drugs or drug preparations are specified in the European Pharmacopoeia (Ph. Eur.): Valerian root (Valerianae radix), Valerian tincture (Valerianae tinctura)

dry extract of valerian prepared with aqueous-alcoholic mixtures (Valerianae extractum hydroalcoholicum siccum), and dry extract of valerian prepared with water (Valerianae extractum aquosum siccum).

In contrast, there is no pharmacopoeial quality description for valerian oil(Valerianae aetheroleum).

Essential oil(Valerianae aetheroleum), monoterpenes (pinene, camphene, myrcene, limonene, sesquiterpenic acid, actinidin, chatinidin, valerianin, iridoids (valepotriates and degradation products), lignans, caffeic acid derivatives, alkaloids.

Sleep-promoting and calming due to its effect on GABA and benzodiazepine receptors. The concentration of GABA in the synaptic cleft is increased and the release of activating neurotransmitters is reduced. Spasmolytic, muscle relaxant.

Please note: effect only sets in after 14 days!

Its effect is based on the interaction of all components. There are no acute effects; an effect only sets in after many days or even weeks. However, sleep onset and sleep quality in general are then improved.

Valeric acid has a sedative, anticonvulsant and mortality-reducing effect; stimulates the release of GABA, inhibits its breakdown and increases GABA in the synaptic cleft.

Valtrate lowers muscle tone

Interaction with the benzodiazepine chloride channel receptor with the following results: Inhibition of the reuptake or release of GABA from the synapses. This reduces excitability to excitatory impulses and inhibits central nervous processes. It binds to the dopamine receptor, the HT1A receptor and the antagonist to the adenosine 1 receptors (has a calming effect and is responsible for drowsiness and vigilance).

Restlessness, nervousness-induced sleep disorders; anxiety in childhood (G47.-, G47.0, F93.2, F51.-)

Daily dose: 400-600 mg; the effect of valerian only sets in after 14 days due to its special pharmacokinetics: the concentration of GABA, the most important inhibitory neurotransmitter, is increased in the synaptic cleft, which reduces the release of excitatory neurotransmitters.

For finished products according to the package insert.

Gastrointestinal complaints: Nausea, abdominal cramps

Pregnancy and lactation due to lack of data. Children under 12 years of age due to lack of data. Simultaneous administration of barbiturates and benzodiazepines - excessive sedation!

Allergy to individual components

Valerian ^Dispert® Drg day or night. ^{Baldriparan®} Night Drg,

Valerian monopreparations: Baldorm® tablets, Valerian Dispert® Day for calming 125 mg tablets, Baldravit®600 mg tablets, Baldurat®650 mg tablets, Cefan® tablets, Dolestan® Valerian 450 mg film-coated tablets, Euvegal®500 Balance film-coated tablets, Ivel® mono 300 mg tablets, Kneipp® Valerian extract, Luvased® mono tablets, Pascosedon® Valerian tablets, Sedonium®300 mg tablets.

Valerian + hop cones: Alluna ®Night Tablets, Ardeysedon® Night Tablets, Valerian Dispert® Night to Fall Asleep Tablets, Kneipp Good Night Sleep Dragees®, Sedaselect® D Dragees, Selon ®Dragees

Valerian + lemon balm leaves: Euvegal® 320/160 mg coated tablets, Euvegal® relaxation and sleep drops, Plantival® forte, -novo tablets, SE Valerian/Melissa forte® film-coated tablets

Valerian + lemon balm leaves + hop cones: Pascosedon® film-coated tablets, Sedacur® forte coated tablets

Valerian + lemon balm leaves + passion flower herb: Phytonoctu ® film-coated tablets, Valeriana Hevert ® sedative lozenges

Valerian + hop cones + passionflower herb: Biosedon® tablets, Kytta® sedative coated tablets, Moradorm® S film-coated tablets, Vivinox sedative coated tablets.

Valerian + St. John's wort: Psychotoninsed Capsules®, Sedariston® Concentrate Capsules

Valerian + St. John's wort or passionflower herb: Neurapasbalance® film-coated tablets, Cor-Select® ointment, Leukona® sedative bath, Leukona® sedative bath sine chloral hydrate, Fugacid® sedative tea®, Gerner Nervinum N, Heumann® sedative tea Tenerval® N, Rhoival® tea

Due to the possible impairment of the ability to react, it is advisable to refrain from driving or operating machinery for several hours.

The combination with hops shows a faster onset of action - the combination is also listed in the HMPC monograph: "well-established use" for the indication of sleep disorders.

The fixed combination "valerian root + hop cones + lemon balm leaves" from:

Valeriana radix (valerian root)

Humulus lupulus (hop cones) and

Melissae folium (lemon balm leaf extract)

has a sedative effect and is prescribed for restlessness, tension and sleep disorders. The combination can also be used in children under 12 years of age.

The fixed combination "Valerian root + lemon balm leaves" from:

Valeriana radix (valerian root)

Melissae folium (lemon balm leaf extract)

has a sedative effect, is prescribed for restlessness and sleep disorders (trade name: Euvegal® 320/160mg film-coated tablets 2-0-2 tablets/day).

The fixed combination "valerian root + hop cones + passion flower herb" from:

Valeriana radix (valerian root) "

Humulus lupulus (hop cones) and

Passiflorae herba (passion flower herb)

has a sedative effect. The combination can also be used in children under 12 years of age.

Other fixed combinations are: Valerian root + St. John's wort (Psychotonin® -sed. Kps. 1-(1)-1)

Valerian root + St. John's wort + lemon balm leaves (SedaristonC® Trofp 20-20-20 drops/day)

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