Podophylline

Authors: Prof. Dr. med. Peter Altmeyer, Prof. Dr. med. Martina Bacharach-Buhles

Last updated on: 29.10.2020

Synonym(s)

Podophyllinum; Podophyllum peltatum extract; Podophyllum resin; resina podophylli

Definition
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Podophyllin is a mixture of substances obtained from the ethanolic extract of the rootstock of the plant Podophyllum peltatum in a special process. Podophyllin is a yellow, toxic, amorphous powder insoluble in water, partially soluble in ammonia and ethanol. Ingredients are the lignans podophyllotoxin and alpha - and beta-peltatins.

Pharmacodynamics (Effect)
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Antimitotic effect by binding to tubulin and inhibiting the formation of microtubules.

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Dermatology

Erythema

Circumscribed, variably sized, polyetiologic (exogenously or endogenously triggered) solitary, sharply or i...

Indication
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Means of the reserve for the therapy of condylomata acuminata.

Dosage and method of use
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Medicine: 5% solution 2 times/day for 3 consecutive days over max. 4 weeks. Let the doctor apply with cotton swab to the condylomas. Caution! The treated skin area must not exceed 25 cm2. Carefully cover the surrounding skin e.g. with pasta zinci mollis. Allow the treated area to dry for at least 1 minute before it comes into contact with clothing.

Cosmetics: The substance is used in cosmetic formulations under the INCI designation "Podophyllum peltatum extract". The extract has a skin caring effect.

Standard concentration
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Up to 15%.

Undesirable effects
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Erythema, dermatitis, burning, trophic disorders, necroses and pigmentation, teratogenicity possible, foreskin constriction (due to swelling).

Notice! Women of childbearing age should use effective contraception under therapy and up to 3 months afterwards!

Interactions
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Alcohol leads to an increase in podophylline toxicity.

Contraindication
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Pregnancy (teratogenic!), lactation, application to the eye, herpes simplex recidivans, applications in children and adolescents < 18 years, M. Bowen ( tendency to cell dysplasia), immunodeficiency, inflamed or bleeding condylomas, simultaneous treatment with other local therapeutics, positive syphilisserology

Note(s)
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Remember! There are no more ready-to-use drugs available for podophyllin. The prescription can therefore only be made as extemporaneous preparation. Preference should be given to ready-to-use preparations containing podophyllotoxin.