Podophyllii rhizoma

Authors: Prof. Dr. med. Peter Altmeyer, Prof. Dr. med. Martina Bacharach-Buhles

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Last updated on: 02.10.2022

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Synonym(s)

Footleaf root; May apple root

Definition
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Podophyllii Rhizoma (off. DAC86, ÖAB90, Ph. Helv.7.) is a mixture, of various, in water insoluble, substances obtained from the ethanolic extract of the footleaf rhizome (rhizome+root) of Pophyllum peltatum, the footleaf. They are soluble in 100 T. Ammonia solution, in 10 T. Ethanol and partially in ether.

Commission E-Monograph: External: pointed condyloma

Experiential medicine: External removal of warts, oncological diseases.

Ingredients
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Ingredients of the extract are the lignans podophyllotoxin and alpha - and beta-peltatine.

Field of application/use
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As 10% solution in 90% ethanol locally against Condylomata acuminata. Furthermore extracts were used as laxative (dosage 10-20mg).

Contraindication
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Podophyllotoxin has a teratogenic effect. No use in pregnancy!

Trade names
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Condylox® solution (apply 2x daily according to doctor's instructions)

Note(s)
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Rhizoma podophyllii is treated with highly diluted hydrochloric acid to obtain podophylline, a highly toxic mixture of substances which is used in ethanolic solution for the treatment of condylomata acuminata.

Podophyllotoxin is a mitosis poison. Derivatives of the podophyllotoxin are introduced as cytostatic drugs (see etoposide, mitoposide, teniposide)

Literature
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  1. Wenigmann M. (2017) Phytotherapy medicinal drugs, phytopharmaceuticals, application. Urban & Fischer, pp. 109-110