DefinitionThis section has been translated automatically.
Methylsulfonylmethane (MSM), also known as dimethylsulfone, is an organic sulfur compoundthat occurs in animal and plant organisms. MSM differs from the synthetically produced solvent dimethyl sulphoxide (DMSO) in that an additional oxygen atom is attached to the sulphur atom. MSM is a white, odorless, somewhat bitter-tasting crystalline substance containing 34% sulfur.
Effect: Inhibition of messenger substances of inflammation, e.g. inflammasomes, which in turn stimulate the secretion
of interleukin (IL)-1β. Studies have demonstrated the inhibition of the release of prostaglandin E2 and the stimulated release of interleukin (IL)-6 and tumor necrosis factor (TNF)-α. Furthermore, antioxidant effects with inhibition of the formation of free oxygen radicals were shown, as well as anti-carcinogenic effects and stimulation of bone metabolism in cell culture.
In 2022, Miller et al. demonstrated an increase in high-density lipoprotein cholesterol in overweight patients in a randomized, double-blind, placebo-controlled study with 22 overweight patients after 8 and 16 weeks of daily administration of MSM.
General informationThis section has been translated automatically.
Sulphur compound, sulphur donor from food, which is quickly absorbed and excreted again. Studies show anti-inflammatory, antioxidant, anti-carcinogenic and bone metabolism-stimulating effects.
LiteratureThis section has been translated automatically.
- https://www.uniklinik-freiburg.de/fileadmin/mediapool/08_institute/rechtsmedizin/pdf/Addenda/Methylsulfonylmethan.pdf
- Debbi EM et al. (2011) Efficacy of methylsulfonylmethane supplementation on osteoarthritis of the knee: a randomized controlled study. BMC Complement Altern Med 27;11:50. doi: 10.1186/1472-6882-11-50. PMID: 21708034; PMCID: PMC3141601.
- Miller L et al. (2021) The Effect of Daily Methylsulfonylmethane (MSM) Consumption on High-Density Lipoprotein Cholesterol in Healthy Overweight and Obese Adults: A Randomized Controlled Trial. Nutrients 15;13(10):3620. doi: 10.3390/nu13103620. PMID: 34684621; PMCID: PMC8540167.