Calendulae flos

Authors: Prof. Dr. med. Peter Altmeyer, Prof. Dr. med. Martina Bacharach-Buhles

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Last updated on: 06.09.2022

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Synonym(s)

flores calendulae; Marigold blossoms

Definition
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Extract from marigold flowers (see also marigold) which can be used medicinally in various applications.

Ingredients: essential oils, the bitter substance calendulin, saponins (calendulosides), triterpenes, beta-carotene, lycopene, flavonoids.

HMPC monograph: Traditional-use: mild inflammation of the skin, minor wounds, mild inflammation of the oral and pharyngeal mucosa.

ESCOP monograph: mild inflammation of the skin and mucous membranes, small wounds.
Commission E-monograph: inflammatory changes of oral and pharyngeal mucosa, wounds with poor healing tendency.

Empirical medicine: prevention of radiation damage, skin care in postoperative irradiation, ulcus cruris.

Pharmacodynamics (Effect)
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Anti-oedematous, antiphlogistic (flavoinides, saponins). The carotenoid derivatives are attributed a granulation-promoting effect.

Indication
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Internally: as a choleretic, emmenagogue, for liver and gallbladder disorders.

Externally: anti-inflammatory(napkin dermatitis, dermatitis solaris), antimicrobial and granulation-promoting effect in ointment bases; use also with badly healing wounds(Ulcus cruris: to this indication however reliable studies are missing).

Furthermore, in inflammatory changes of the oral and pharyngeal mucosa. Positive monographs of Commission E, HMPC, WHO and ESCOP (European Scientific Cooperative on Phytotherapy) are available.

Pregnancy/nursing period
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Fertility, pregnancy and lactation: Safety during pregnancy and lactation has not been established. In the absence of sufficient data, use during pregnancy and lactation is not recommended. No data on fertility are available (HMPC).

Dosage and method of use
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1-2g drug to 1 cup of water (150ml).

1-2 teaspoons (2-4ml) of tincture to 250 -500ml of water.

As preparations in ointments: 2.0-5.0g drug to 100g ointment.

Undesirable effects
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Contact allergic reactions, especially in patients with known sensitisations against composites.

Contraindication
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Allergies to daisy family (Asteraceae).

Pregnancy and lactation due to lack of safety studies.

Children under 6 years of age due to insufficient data.

Preparations
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In addition to the traditional infusions for poultices, ready-made Calendula ointments (Calendumed® cream) - creams, essences and skin care oils are available. Calendula cream

Literature
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  1. Aro AA et al.(2014) Effect of Calendula officinalis cream on achilles tendon healing. Anat Rec (Hoboken) 298:428-435.
  2. Calendulae flos. Commission-E/BGA comments.
  3. Calednulae flos. HMPC comments.
  4. D'Ambrosio M et al. (2015) Structure and cytotoxic activity of sesquiterpene glycoside esters from Calendula officinalis L.: Studies on the conformation of viridiflorol. Phytochemistry 117:1-9.
  5. Kodiyan J et al. (2015) A Review of the Use of Topical Calendula in the Prevention and Treatment of Radiotherapy-Induced Skin Reactions. Antioxidants (Basel) 4:293-303.
  6. Mahmoudi M et al. (2015) Comparing the effects of Bentonite & Calendula on the improvement of infantile diaper dermatitis: A randomized controlled trial. Indian J Med Res 142:742-746.
  7. https://arzneipflanzenlexikon.info/ringelblume.php.
  8. https://www.ema.europa.eu/en/documents/herbal-monograph/final-european-union-herbal-monograph-calendula-officinalis-l-flos-revision-1_en.pdf
  9. Wenigmann M. (2017) Phytotherapy medicinal drugs, phytopharmaceuticals, application. Urban & Fischer, pp. 179-180