Agrimoniae herba

Authors: Prof. Dr. med. Peter Altmeyer, Prof. Dr. med. Martina Bacharach-Buhles

All authors of this article

Last updated on: 14.10.2021

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Synonym(s)

Agrimony; Braids; Burdock; cinquefoil; Field cabbage; Folia Agrimoniae; Greek liverwort; Herba Agrimoniae; Herba Eupatoriae; Ottermint; Rockroot; Rock Root; Stubwort; Warbler; weed; Winchweed

Definition
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Agrimoniae herba, also known as agrimony, is a Commission E and ESCOP positive monograph drug used in herbal medicinal products for the treatment of, inter alia, diarrhoeal diseases and mucosal inflammation. The drug consists of the cut and dried shoot tips of the above-ground plant during the flowering season.

HMPC: Traditional use: mild diarrhoea, moderate inflammation of throat and pharynx, skin and skin wounds.

ESCOP monograph: internally for mild diarrhea; externally for gargling for inflammation of the mucous membranes of the mouth and throat, as a compress or rinse to aid wound healing;

Commission E mon ograph: internally for mild, non-specific diarrhoea; externally for inflammation of the mucous membranes of the mouth and throat, for mild, superficial inflammation of the skin.

Ingredients
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Agrimoniae herba contains 4% to 10% catechin tanning agents (according to Ph. Eur. at least 2%), flavonoids, phenolic carboxylic acids and triterpenes, including ursolic acid.

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Internal medicine

Effects
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Agrimoniae herba relieves existing itching in inflammatory skin diseases (Commission E, ESCOP), has a mild anesthetic effect, also has astringent, antiphlogistic, bacteriostatic and antiviral effects.

Field of application/use
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Agrimony herb is used in accordance with the guidelines of Commission E for mild, non-specific and acute diarrhoea, mild inflammation of the skin and inflammation of the mouth and throat mucosa. According to ESCOP, WHO and HMPC monographs, agrimony herb is also used for external application as a compress or as an irrigation to support wound healing.

Dosage
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The daily dose of the drug agrimony lies between 3 and 6 g. In case of external use, use compresses with a 10% decoction several times a day.

Undesirable effects
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Photoallergic reactions possible after local application of the drug and subsequent UV exposure.

Contraindication
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Allergies to individual ingredients. For children under 12 years, as well as for pregnant women and nursing mothers no data are available.

Interactions
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There are no known interactions with other drugs. However, when used internally, it is possible that other drugs taken at the same time may be inhibited.

Literature
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  1. Bae H et al. (2010) Inhibitory effect of
  2. Agrimoniae Herba on lipopolysaccharide-induced nitric oxide and proinflammatory cytokine production in BV2 microglial cells. Neurol Res 32 Suppl 1:53-57.
  3. Granica S et al. (2015) The phytochemical investigation of Agrimonia eupatoria L. and Agrimonia procera Wallr. as valid
  4. sources of Agrimoniae herba--The pharmacopoeial plant material. J Pharm Biomed Anal 114:272-279.
  5. Qu D et al.(2014) Synthesis and in vitro antineoplastic evaluation of silver nanoparticles mediated by Agrimoniae herba extract. Int J Nanomedicine. 9:1871-1882.https://www.ncbi.nlm.nih.gov/pubmed/24790429
  6. Schilcher H (2016) in: Leitfaden Phytotherapie, Urban & Fischer Verlag Munich, pp. 233 f.
  7. https://arzneipflanzenlexikon.info/odermennig.php