Migraine

Last updated on: 25.02.2026

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Definition
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Seizure-like, usually half-sided headache with or without aura, nausea, possibly vomiting and diarrhea, chronic clinical picture.

Note(s)
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There is evidence of a link between migraines and rosacea. In a large Danish study, 12.1% of rosacea patients (16% of women, 4% of men) suffered from migraines (in the general population, the figure was only 7.3% (Egeberg A et al. 2017). Elevated CGRP levels in the blood are found in both diseases. CGRP is one of the most widespread peptides with diverse biological functions. Alpha-CGRP is one of the most potent vasodilators. Both peptide variants exert their effect via membrane-bound receptors. These receptors are found in the brain, heart, smooth and striated muscles, skin, lungs and gastrointestinal tract. Their activation leads to vasodilation, edema, increased blood flow with recruitment of inflammatory cells and inflammation

Endometriosis: Migraine also occurs with endometriosis: CGRP could also be a common pathophysiological factor here (Jenabi E et al. 2020).

Literature
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  1. Egeberg A et al. (2017) Prevalence and risk of migraine in patients with rosacea: A population-basedcohort study. J Am Acad Dermatol 76: 454-458.
  2. Jenabi E et al. (2020) Endometriosis and migraine headache risk: a meta-analysis. Women Health. 60: 939-945.

Last updated on: 25.02.2026