Hypercalcemia E83.58

Last updated on: 11.02.2023

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Hypercalcemia is an electrolyte disorder and is defined in adults as total calcium i.s. >2.7nmol/l; ionized calcium > 1.3nmol/l.

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The causes of more than 80% of hypercalcemia are due to malignancies with osteoclastic metastases and parathyroid hyperfunction.

Less common causes include immobilization due to osteoporosis, sarcoidosis, and severe fractures.

Familial hyocalcemias:

  • Idiopathic infantile hypercalcemia: mutation of CYP24A1.
  • Familial hypocalcuric hypercalcemia (FHH): Autosomal dominant mutation with disturbances in the calcium-sensing receptor signaling pathway.

Clinical features
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Possibly symptoms of an underlying tumor disease.

Hypercalcemia symptoms:

  • Kidney: Polyuria and polydipsia(renal diabetes insipidus) - if left untreated may lead to exsiccosis, anuria, nephrolithiasis and nephrocalciosis.
  • Nervous system: headache, psychosis, somnolence and even coma.
  • gastrointestinal symptoms: nausea, vomiting and weight loss
  • Other: Bone pain and cardiac arrhythmias.

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Forced diuresis, stop calcium intake, for tumor-induced hypercalcemia. Biphosphonates


Please ask your physician for a reliable diagnosis. This website is only meant as a reference.

Last updated on: 11.02.2023