Author: Prof. Dr. med. Peter Altmeyer

All authors of this article

Last updated on: 29.10.2020

Dieser Artikel auf Deutsch

This section has been translated automatically.

Composite art term made up of "granules" and "enzymes". The term "granzyme" refers to proteases that are active in the intracellular granules of defence cells, especially in cytotoxic (CD8+) T cells. To date, > 10 different granzymes are known (A to M). Granzymes are assisted by the enzyme perforin, which docks to the membranes of target cells and creates pore-like structures there. After the formation of pores by Perforin, granzymes can digest the amino acid serine. Granzymes, together with Perforin, are thus responsible for the apoptosis of endogenous and foreign cells. Thus, their importance lies in the defence against infections, transplanted foreign tissue, tumour cells and autoimmune diseases (see also lichen planus, lichenoidal drug exanthema, panniculitis-like T-cell lymphoma ).

This section has been translated automatically.

  1. da Silva Santos C, Attarha S et al (2014) Proteome profiling of human cutaneous leishmaniasis lesion. J Invest Dermatol 135:400-410
  2. Fogagnolo L, Soares TC et al (2014) Cytotoxic granules in distinct subsets of cutaneous lupus erythematosus. Clin Exp Dermatol 39:835-839
  3. Gaber MA et al (2014) Immunohistochemical expression of perforin in lichen planus lesions. Ultrastruct catheter 38:413-419
  4. Rönnberg E, Calounova G et al (2014) Granzyme H is a novel protease expressed by human mast cells. Int Arch Allergy Immunol 165: 68-74
  5. Su Y, Jevnikar AM, Huang X et al (2014) Spi6 protects alloreactive CD4(+) but not CD8 (+) memory T cell from granzyme B attack by double-negative T regulatory cell. At J transplant 14: 580-593


Last updated on: 29.10.2020