DefinitionThis section has been translated automatically.
Very rare, primary T-cell lymphoma of the skin, in which the tumor cells by definition exhibit the phenotype of cytotoxic T-cell with expression of CD3 and CD8 (see below for an overview of lymphoma, cutaneous T-cell lymphoma, cytotoxic). CD8+ CTCL is characterized by its own clinical and immunohistological characteristics and a well defined aggressive course.
Clinical featuresThis section has been translated automatically.
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HistologyThis section has been translated automatically.
Histology: Predominantly image as in mycosis fungoides or pagetoid reticulosis with band-shaped, diffuse infiltrate of small, medium or large immunoblastic pleomorphic, distinctly epidermotropic T cells. The epidermis is acanthotic with different, but mostly very dense lymphocytic infiltrates.
DiagnosisThis section has been translated automatically.
Differential diagnosisThis section has been translated automatically.
- Cutaneous T-cell lymphomas of other origins (see below lymphoma, cutaneous T-cell lymphoma).
- Mycosis fungoides: Clinically varied and variable picture (time interval from first symptoms to diagnosis: 4.2 years!). Skin symptoms develop very slowly (months to years). Systemic involvement is only detectable after a longer clinical course. Typical clinical course of lymphoma in 3 stages.
Pagetoid reticulosis "disseminated type" (Ketron and Goodman): Especially in older men, disseminated, reddened, rapidly growing, scaly plaques and nodules. Tendency to generalization.
Notice! These are probably T-cell lymphomas which must be classified as CD8+ cutaneous T-cell lymphomas.
TherapyThis section has been translated automatically.
Progression/forecastThis section has been translated automatically.
Bad prognosis. The mean survival time is about 32 months.
LiteratureThis section has been translated automatically.
- Berti E et al (2009) Primary cutaneous CD8-positive epidermotropic cytotoxic T cell lymphomas. At J cathode 155: 483-492
- Gormley RH et al (2010) Primary cutaneous aggressive CD8+ T cell lymphomas. Am J Acad Dermatol 62: 300-307
- El-Shabrawi-Caelen L et al (2000) The clinicopathologic spectrum of cytotoxic lymphomas of the skin. Sem Cutan Surg 19:118-123
- Santucci M et al (2003) Cytotoxic/natural killer cell cutaneous lymphomas. Report of EORTC Cutaneous Lymphoma Task Force Workshop. Cancer 97: 610-627
Incoming links (1)Primary cutaneous cd8-positive aggressive epidermotropic cytotoxic t-cell lymphoma;
Outgoing links (7)Bexaroten; Cutaneous t-cell lymphomas (overview); Cytotoxic t-lymphocyte; Granzyme; Mycosis fungoides (overview); Pagetoid reticulosis; Perforin;
Please ask your physician for a reliable diagnosis. This website is only meant as a reference.