Candida albicans

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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History
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Gruby, 1842; Robin, 1853

General definition
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Potentially human pathogenic yeast fungus (shoot). C. albicans reproduces primarily by sprouting, but can also form hyphae and pseudohyphae (dimorphism). C. albicans is a human commensal (gastrointestinal tract; vagina). Morphologically, the step from the commensal to the pathogenic phase is characterized by the transition from the yeast to the mycelium phase.

On standard media, the Candida species show the typical growth behaviour after 1-4 days with the formation of white cream-coloured or red colonies with a matt shiny surface and a typical, intensive "smell of yeast".

Pathogen
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virulence factors of Candida albicans.

  • Colonization - short regeneration times - wide pH and temperature range - adherence to epithelium (mannoproteins)
  • Tissue invasion, lytic enzymes, formation of suitable morphological structures(germ tubes; pseudomycel): Candida albicans forms proteinases, especially secretory aspartate proteases (SAP's), phopholipases and lysophospholipases with hydrolytic properties. These enzymes enable the enzymatic digestion of the tissue. Furthermore, Candida albicans is able to form toxins; a cytolytic peptide toxin called candidalysin has been detected. Candidalysin forms holes in the membrane of host cells and thus destroys them (Moyes d et al. 2016).
  • Tissue persistence "phenotypic switch" , "antigenic mimicry" = masking with endogenous structures

Occurrence/Epidemiology
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Worldwide spread. Natural reservoir are human mucous membranes. Common in newborns, diabetics, malignant primary diseases, immunocompromised persons. Most common potentially human pathogenic yeast fungus (90% of all yeast diseases are caused by C. albicans).

Clinical picture
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Diverse, superficial clinical pictures, especially in the warm and humid regions of the body; clinic see below candidiasis.

Microscopy
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Hyphae and pseudohyphae (may be missing depending on the growing medium). Germination tube formation, pseudomyzel.

Round, unicellular blastoconidia along the hyphae and especially on septa.

Chlamydospores: Round to oval, mostly terminal (less often intercalary), thick-walled, size: 6-17 μm Ø.

Notice! Differentiation of Candida albicans is done on rice agar (incubation time up to one week at room temperature)! C. albicans develops chlamydospores on this agar.

Note(s)
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Known and defined allergens for Candida albicans are:

  • Cand a 1 alcohol dehydrogenase
  • Cand a 3 peroxysomal protein

Literature
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  1. Korting HC, Schaller M (2001) New developments in medical mycology. dermatologist 52: 91-97
  2. Moyes DL et al (2016) Candidalysin is a fungal peptide toxin critical for mucosal infection. Nature 532:64-8.
  3. Seebacher C (1999) Candida in dermatology. Mycoses 42: S63-S67
  4. Snydman DR (2003) Shifting patterns in the epidemiology of nosocomial Candida infections. Chest 123: 500S-503S
  5. von Langenbeck BRC (1839) Detection of fungi on the mucous membrane of the esophagus of a typhoid cadaver. In: New note Geb Natur-u. Heilkunde

Outgoing links (2)

Candidoses; Germ tube test;

Disclaimer

Please ask your physician for a reliable diagnosis. This website is only meant as a reference.

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Last updated on: 29.10.2020