Amphotericin b

• For candidiasis of the oral mucosa and enteral candidiasis as a reserve preparation: 4 times/day 100-200 mg as suspension or tablets.
• For systemic infections: first a test dose of 1-2 mg i.v., then 0.1 mg/kg bw i.v. with gradual increase to a maximum of 1 mg/kg bw/day.
• Children from 3 months: 0.25-1 g/day i.v., infusion for at least 6 hours.

Notice! In case of i.v.-application administration of 1-2 mg in 20 ml 5% dextrose as test dose, observation of the patients over 4 hours, if well tolerated, therapy can be started!

In systemic application, electrolyte disorders such as hypokalemia, renal tubular acidosis, and urea and creatinine elevation are among the most common ADRs. Often also fever, malaise, chills, allergic skin reactions up to anaphylaxis, headache, rigor, phlebitis, thrombophlebitis, anemia, weight loss, vomiting, visual disturbances, arthralgias, myalgias, severe feeling of illness. Haemato- and nephrotoxicity (see below acute tubulointerstitial nephritis) with parenteral application.

Notice! Pay attention to paragroup allergy in finished preparations.

Notice! During the first 4 weeks of therapy the following laboratory parameters should be checked twice a week and then weekly: haematocrit, electrolytes, blood count, creatinine, urine status and sediment. A dosage of > 4 g over 6 weeks generally leads to irreversible damage to kidney function!

Major interactions of Amphotericin B