Acladiosis - Altmeyers Encyclopedia - Department Dermatology

Synonym(s)

Acladiosis

Definition
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Tropical infection with Acladium castellanii Pinoy, which belongs to the mould diseases.

Clinic
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Sharp-edged, encrusted ulcers on the skin.

Differential diagnosis
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Sporotrichosis.

Internal therapy
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Antimycotics, e.g. Amphotericin B, starting with 0.1 mg/kg bw/day i.v., slow dose increase to 1.0 mg/kg bw/day i.v., alternatively Flucytosin (e.g. Ancotil) 150-200 mg/kg bw/day i.v. in 4 ED. In severe cases combination of both preparations. Antimycotics from the group of azoles show only limited effectiveness against moulds, e.g. itraconazole (Sempera Kps.) 1-2 times 100-200 mg/day p.o.