Use use test

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Definition
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Epicutaneous test procedure for clarifying an unclear or questionable test reaction to better assess clinical relevance. Modification of a " repeated open application test".

Indication
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Assessment of the clinical relevance of sensitization to cosmetic ingredients using finished products.

Implementation
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  • Application of the finished product 2 times/day for 1 week at a defined body area.
  • The chosen localisation should correspond to the normal application.
  • If possible, carry out a negative control: ideally a comparable product without the suspected allergen.
  • The test reaction is then evaluated according to the conditions of the standard epicutaneous test.
  • Indication of clinical relevance in the allergy certificate (see COADEX index below).

Literature
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  1. Villarama CD et al (2004) Correlations of patch test reactivity and the repeated open application test(ROAT)/provocative use test (PUT). Food Chem Toxicol 42: 1719-1725

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Last updated on: 29.10.2020