DefinitionThis section has been translated automatically.
Index to record the most important, practical criteria regarding the clinical relevance of type IV sensitization.
General informationThis section has been translated automatically.
After reading an epicutaneous test or photopatch test, an evaluation of the clinical relevance of the type IV sensitization present must always be made. All information should then be documented for the patient in an allergy pass. It is useful to indicate the clinical relevance with reference to the allergen in the passport. The so-called COADEX index comprises the most important, practice-relevant criteria regarding clinical relevance:
- C (current): current clinical relevance. The patient was exposed to the allergen and now presents with clinical symptoms, which will however improve when the patient is not exposed to the allergen.
- O (old): past clinical relevance. The patient has been exposed to the allergen in the past and developed clinical symptoms, but these are not present.
- A (actively sensitized): the patient is actively sensitized.
- D (do not know): relevance remains unclear.
- EX (exposed): history of allergen exposure without clinical symptoms or no history of allergen exposure in case of positive type IV sensitization in the epicutaneous test.
Note(s)This section has been translated automatically.
The clinical relevance of sensitization to finished products (e.g. cosmetics) can be determined by means of a use-use test.
LiteratureThis section has been translated automatically.
- Bourke J et al (2001) Guidelines for care of contact dermatitis. Br J Dermatol 145: 877-885
- Bruynzeel DP et al (2004) Photopatch testing: a consensus methodology for Europe. J Eur Acad Dermatol Venereol 18: 679-682
- Villarama CD et al (2004) Correlations of patch test reactivity and the repeated open application test(ROAT)/provocative use test (PUT). Food Chem Toxicol 42: 1719-1725
Prof. Dr. med. Peter Altmeyer