Squamous cell carcinoma, spindle cell

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Synonym(s)

pleomorphic squamous cell carcinoma; spindle-cell squamous cell carcinoma

Definition
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Rare, aggressively growing squamous cell carcinoma of the skin characterized by a high propensity to metastasize.

Clinical features
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The tumour clinically impresses with a fast-growing, mostly ulcerated, red or skin-coloured lump.

Histology
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Histologically, the tumor is characterized by spindle-cell, undifferentiated, cytokeratin positive, eosinophilic epithelial formations embedded in a connective tissue stream. Evidence of numerous nuclear polymorphisms and mitoses. Occasionally also multinuclear epithelial giant cells. Differentiations with formation of horny beads are mostly missing.

Differential diagnosis
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The most important histological differential diagnosis is the atypical fibroxanthoma (AFX).

Therapy
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Excision with a sufficient safety distance to all sides.

Literature
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  1. Defty CL et al(2011) Basaloid squamous cell carcinoma with 'monster' cells: a mimic of pleomorphic basal cell carcinoma. J Cutan catheter 38:354-356.
  2. Ellis R et al(2015) Pleomorphic spindle cell dermal neoplasm with dot-like keratin reactivity: keratin-positive AFX or carcinoma? J Cutan catheter 42:847-852.
  3. Kanner WA et al(2010) CD10, p63 and CD99 expression in the differential diagnosis of atypical fibroxanthoma, spindle cell squamous cell carcinoma and desmoplastic melanoma. J Cutan pathogen 37:744-750.
  4. Lagana SM et al(2011) Pleomorphic (spindle and squamous cell) carcinoma arising in a peripheral mixed squamous and glandular papilloma in a 70-year-old man. Arch Pathol Lab Med 135:1353-1356.

Outgoing links (1)

Fibroxanthoma atypical;

Disclaimer

Please ask your physician for a reliable diagnosis. This website is only meant as a reference.

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Last updated on: 29.10.2020