Retapamulin
Synonym(s)
Retapamulinum
Definition
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Antibiotic from the pleuromutiline group.
Pharmacodynamics (Effect)
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Inhibition of protein synthesis by binding to the 50s subunit of the 70s ribosomes of bacteria.
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Spectrum of action
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Retapamulin has a bacteriostatic effect against Staphylococcus aureus and Streptococcus pyogenes by inhibiting bacterial protein synthesis via ribosomal binding. The binding site is different from other antibiotics. It is not effective against Gram-negative bacteria (e.g. Escherichia coli and Haemophilus influenzae).
Indication
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Approved for topical treatment of impetigo and other skin infections from the age of 9 months.
Dosage and method of use
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Cream 1%: Apply 2 times/day, use for 5 days
Standard concentration
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1% cream
Preparations
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Altargo®
Literature
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- Rittenhouse S et al (2006) Selection of retapamulin, a novel pleuromutilin for topical use. Antimicrob Agents Chemother 50: 3882-3885
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Prof. Dr. med. Peter Altmeyer