Protionamide
Synonym(s)
PTH
Definition
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Half-life
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2–4 h
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Indication
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Combination therapy of tuberculosis, especially for isoniazid resistance.
Limited indication
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Chronic alcohol abuse, gastrointestinal ulcers, acute gastritis.
Dosage and method of use
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- adults: 5-15 mg/kg bw/day p.o. or i.v.
- children: 15-25 mg/kg bw/day p.o./i.v.
- Infants/children: 4 years 25 mg/kg bw/day.
- children 5-8 years 20 mg/kg bw/day.
- children > 9 yrs. 15 mg/kg bw/day.
Undesirable effects
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Myelosuppression, hypoglycemia, gynecomastia, hypothyroidism, gastrointestinal disorders, metallic taste, hepatitis, jaundice, allergic reactions, pellagroid symptoms, peripheral and central nervous disorders, dizziness, headache, depression, seizures.
Interactions
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See Table 1.
Contraindication
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1st trimester pregnancy, lactation, severe liver dysfunction, convulsions, psychosis.
Preparations
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Ektebin, Peteha
Tables
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Major interactions of protionamide
Alcohol |
Central nervous effects ↑ |
Antidiabetic agents, oral |
|
Barbiturates |
Barbiturate degradation ↓ |
Insulin |
|
Isoniazid |
Hepatotoxic and central nervous effects ↑ |
Pyrazinamide |
hepatotoxic effects ↑ |
Rifampicin |
hepatotoxic effects ↑ |
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Prof. Dr. med. Peter Altmeyer