Proteases

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Synonym(s)

Endopeptidases; Exopeptidases; Proteinases

Definition
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Proteolytic enzymes belonging to the enzyme family of hydrolases. Proteases hydrolytically cleave the peptide bonds contained in oligo-, polypeptides or proteins (proteolysis). Depending on the substrate, longer-chain protein fragments, short-chain cleavage peptides or free amino acids are formed.

Classification
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Depending on the degradation mechanism, proteases are released in:

  • endopeptidases (enzymes by which peptides or proteins inside the polymeric chains are hydrolytically cleaved): chymotrypsin, elastase, trypsin
  • Exopeptidases (enzymes by which peptides or proteins are gradually hydrolytically degraded to amino acids from the chain end.

Literature
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Tedeschi A et al (2014) Chronic urticaria and coagulation: pathophysiological and clinical aspects.
Allergy 69:683-691.

Outgoing links (1)

Enzymes;

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Last updated on: 29.10.2020