HistoryThis section has been translated automatically.
DefinitionThis section has been translated automatically.
Not rare, hereditary or non-hereditary, acquired, disseminated form of porokeratosis in light-exposed areas. The single florescence is a punctually beginning, centrifugally progressive hyperkeratosis with development of a ring-shaped, parakeratotic cornea and central atrophy.
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EtiopathogenesisThis section has been translated automatically.
- In some patients an irregular autosomal dominant inheritance can be demonstrated.
- Several cytogenetic aberrations have been detected on the following gene loci: 1p31.3-p31.1 - 15q25.1-q26.1 and others
- However, most patients deny a familial occurrence.
- Excessive UV exposure can be detected in almost all cases. A combination with immunosuppression (HIV infection; immunosuppressive therapies) is not uncommon.
- Disseminated superficial eosinophilic porokeratosis can be drug-induced (thiazides) or occur spontaneously.
ManifestationThis section has been translated automatically.
Mostly occurring in fair-skinned adults with increased sun exposure, mostly 40th-50th LJ, women seem to be preferentially affected.
LocalizationThis section has been translated automatically.
Back of the hand, forearm extension sides, lower leg extension sides, no mucosal involvement.
Clinical featuresThis section has been translated automatically.
Round to oval, 0.2-0.5-1.5 cm large, skin-coloured or brownish-red, slightly sunken horn papules or plaques with sharply defined, hyperkeratotic rim wall.
HistologyThis section has been translated automatically.
Differential diagnosisThis section has been translated automatically.
TherapyThis section has been translated automatically.
- Physical procedures such as curettage or ablative laser (Co2 or Erbium-YAG laser)
- vitamin D3 analogues
- Fluorouracil Therapy
- Photodynamic Therapy
- In a smaller study (Schilling B 2018), good results were obtained with so-called boundary rays (long-wave, soft X-rays)
- Light protection (e.g. Anthelios), see below light protection agent.
Progression/forecastThis section has been translated automatically.
Notice! Provocation by UV rays and drugs (thiazides)!
Note(s)This section has been translated automatically.
Superficial eosinophilic porokeratosis: As a special form, "Superficial eosinophilic porokeratosis" is described with eosinophilic spongiosis and intraepidermal microabscesses.
Eruptive pruriginous papular porokeratosis: A further, but very rare variant (up to now <15 cases have been described) is the "Eruptive pruriginous papular porokeratosis" which is characterized by a sudden itching. The plumelike parakeratosis zones are related to the follicle. Eosinophilic granulocytes are also an essential part of the inflammatory infiltrate in this form.
LiteratureThis section has been translated automatically.
- Altmeyer P et al (1988) Disseminated superficial eosinophilic porokeratosis. Act Dermatol 14: 287-289
- Besenhard HM et al (1988) Disseminated superficial actinic porokeratosis (DSAP) with Bowen's disease. Dermatologist 39: 286-290
- Biswas A (2015) Cornoid lamellation revisited: apropos of porokeratosis with emphasis on unusual clinicopathological variants. On J Dermatopathol 37:145-155
- Boente Mdel C et al (2003) Linear porokeratosis associated with disseminated superficial actinic porokeratosis: a new example of type II segmental involvement. Pediatric Dermatol 20: 514-518
- Chernosky ME, Freeman RG (1967) Disseminated superficial actinic porokeratosis. Arch Dermatol 96: 611-624
- Chernosky ME, Anderson DE (1969) Disseminated superficial actinic porokeratosis: clinical studies and experimental production of lesions. Arch Derm 99: 401-407
- Nayeemuddin FA et al (2002) Topical photodynamic therapy in disseminated superficial actinic porokeratosis. Clin Exp Dermatol 27: 703-706
- Schilling B (2018) Boundary radiation in refractory actinic porokeratosis: a well tolerated and effective therapy. Bare compass 6:32-33
- Schwarz T et al (1984) Disseminated superficial actinic porokeratosis. J Am Acad Dermatol 11: 724-730
- Sidwell RU et al (2003) Giant actinic porokeratosis of the scalp. Br J Dermatol 149: 654
- Takahashi H et al (2015) Disseminated superficial actinic porokeratosis in a psoriasis patient with a long-term sun-bathing habit. J Dermatol 42:532-533
- Theng CT et al (2004) Warty nodules on an annular plaque in a renal transplant recipient. Arch Dermatol 140: 121-126
- Thomas C et al (2003) Hypertrophic perianal porokeratosis in association with superficial actinic porokeratosis of the leg. Clin Exp Dermatol 28: 676-677
- Torkamani N et al (2015) Disseminated superficial actinic porokeratosis accentuated by spray tan. Int J Dermatol 54:e545-546
Incoming links (8)Actinic porokeratosis; Disseminated porokeratosis; Disseminated superficial actinic porokeratosis; Eruptive pruritic papular porokeratosis; Porokeratosis disseminated superficial actinic; Porokeratosis mibelli; Punctured palmoplantar keratosis type 2; Superficial eosinophilic porokeratosis;
Outgoing links (9)Acrokeratosis verruciformis; Actinic keratosis; Keratosis follicularis; Light protection; Light stabilizers; Porokeratoses (overview); Porokeratosis mibelli; Psoriasis vulgaris; Verrucae planae juveniles;
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