DefinitionThis section has been translated automatically.
Non-immunological reaction that occurs at the first contact with the photosensitizer and in every human being if the dose of the substance is sufficient and followed by appropriate UV irradiation. S.u. phototoxic dermatitis.
DiagnosisThis section has been translated automatically.
See below photo allergy.
Note(s)This section has been translated automatically.
The penetration depth of light rays into human skin is between 0.2 and 4 mm, depending on wavelength and skin area. As the vascular-free stratum corneum is only about 10-150 µm thick, active substances circulating in the blood or in the skin can absorb light. Numerous substrates for phototoxic reactions are available to the excited active agent molecules. Phototoxic reactions occur in vivo and have to be distinguished from skin lesions which may be caused by photostable active substances or excipients. See below active substances, photostable.
LiteratureThis section has been translated automatically.
- Epstein JH (1999) Phototoxicity and photoallergy. Seminar Cutan Med Surg 18: 274-284
- Nigen S et al (2003) Drug eruptions: approaching the diagnosis of drug-induced skin diseases. J Drugs Dermatol 2: 278-299
Incoming links (6)Active ingredients, photoinstable; Benedictine herb; Hyperpigmentation chemical; Melanodermatitis toxica; Methoxsalen; Photoallergic dermatitis;
Outgoing links (4)Active ingredients, photoinstable; Photoallergy (overview); Photosensitizers; Phototoxic dermatitis;
Please ask your physician for a reliable diagnosis. This website is only meant as a reference.