Pentoxifylline

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 12.11.2021

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Definition
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Peripheral vasodilator.

Half-life
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1–1,5 h

Indication
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Claudication intermittens, peripheral arterial circulatory problems.

Limited indication
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Pregnancy, lactation, severe cardiac arrhythmia, coronary sclerosis, renal insufficiency, cerebral sclerosis.

Dosage and method of use
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  • Peroral application: Initially 200-400 mg p.o. 3 times/day, later on 100 mg 3 times/day if necessary. Alternatively: Initially 2 times/day 600 mg retard form p.o., later possibly 2 times/day 400 mg.
  • Intravenous application: Initial 100 mg in 300 ml 0.9% NaCl solution within 90-180 min. i.v., increase by 100 mg/day up to max. 1.2 g.

Undesirable effects
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Dyspnoea, BB changes, gastrointestinal disorders, cholestasis, hepatitis, dry mouth, allergic reactions, vasculitis, cardiac arrhythmia, tachycardia, headaches, confusion, dizziness, visual and hearing disorders, polydipsia, shock.

Interactions
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See Table 1.

Contraindication
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Hypersensitivity to methylxanthines, severe arteriosclerosis, acute bleeding, fresh myocardial infarction, extensive retinal bleeding, peptic ulcer.

Preparations
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Trental, pentoxifyllin-ratiopharm

Tables
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Major drug interactions of pentoxifylline

ACE inhibitors

RR drop ↑

Antihypertensives

RR drop ↑

β -receptor blockers

RR decline ↑

Calcium antagonists

RR decline ↑

Coumarins

Bleeding tendency

Diuretics

RR drop ↑

Heparin

Bleeding tendency

Insulin

Hypoglycemia

Metformin

Hypoglycemia

Outgoing links (1)

Intermittent claudication;

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Last updated on: 12.11.2021