Pellagra, symptomatic E52.x

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Synonym(s)

Prosperity Peakagra; secondary pellagra; Secondary pellagra

Definition
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pellagra as a result of a severe absorption disorder, e.g. in chronic alcoholism ("prosperity pellagra"), severe enteritis, in the context of a carcinoid syndrome), malabsorption or in the case of drug treatment.

Etiopathogenesis
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Drug-induced by drugs such as 5-fluorouracil, 6-mercaptopurine, azathioprine, diphenylhydantoin (anticonvulsants), benzodiazepines (diazepam), ethenzamide, ethionamide (synthetic tuberculostatics), isoniazid, paracetamol, phenobarbital, salicylamide.

Therapy
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Treatment of the underlying disease (e.g. alcoholism, enteritis), if necessary discontinuation of the medication causing the disease. Substitution therapy with nicotinamide, see below pellagra.

Literature
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  1. Hawn LJ et al (2003) A case of pellagra and a South Carolina history of the disorder. JSC Med Assoc 99: 220-223
  2. Heyer G et al (1998) Dose-dependent pellagroid skin reaction caused by carbamazepine. dermatologist 49: 123-125
  3. Karthikeyan K (2002) Pellagra and skin. Int J Dermatol 41: 476-481
  4. Stadler R et al (1982) Medication induced pellagra. Dermatologist 33: 276-280
  5. Stevens HP et al (1993) Pellagra secondary to 5-fluorouracil. Br J Dermatol 128: 578-580
  6. Wallengren J et al (2002) Pellagra-like skin lesions associated with Wernicke's encephalopathy in a heavy wine drinker. Acta Derm Venereol 82: 152-154

Disclaimer

Please ask your physician for a reliable diagnosis. This website is only meant as a reference.

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Last updated on: 29.10.2020