HistoryThis section has been translated automatically.
DefinitionThis section has been translated automatically.
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EtiopathogenesisThis section has been translated automatically.
ManifestationThis section has been translated automatically.
Any age group, m>f; occurrence also described in childhood.
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Clinical featuresThis section has been translated automatically.
- Localized type (Woringer-Kolopp): Initially described, mostly asymptomatic, sharply limited, moderately intense erythema with varying scaling and very slow growth tendency. Over the years, increasing infiltration of the lesion with formation of a disc-shaped, red or reddish-brown, slowly appositionally growing, scaly, possibly also hyperkeratotic plaque. Formation of arcuate and ring-shaped lesions. In the case of long duration, extensive erosions and ulcer formation.
- Disseminated type (Ketron and Goodman): Disseminated, reddened, rapidly growing, scaly plaques, especially in older men. Tendency to generalization.
Notice! These are probably T-cell lymphomas which must be classified as CD8+ cutaneous T-cell lymphomas (see below lymphoma, cutaneous T-cell lymphoma, cytotoxic (CD8-positive)).
Notice! In contrast to Mycosis fungoides a systemic involvement is missing. The life expectancy is not limited.
HistologyThis section has been translated automatically.
- Acanthoid widened epidermis, papillomatosis, pagetoid penetration of the epidermis and epidermal adnexa with medium to large, atypical lymphoid cells These show prominent, chromatin dense, partially indented nuclei. A pronounced "halo reaction" of the exophytic lymphoid cells is typical (in HE section optically empty cytoplasm around the nucleus, see below Mycosis fungoides). As a result, the epidermis is spongy in places. Conspicuously few mitoses are detectable. The dermis shows low perivascular round cell infiltrates (small lymphocytes).
- Electron microscopy: Intraepidermal Lutzner cell-like and blister-like cells.
- Immunohistology: Tumor cells CD3, CD4, CD5 pos.; rarely CD30 pos.; some cases with CD4 neg. and CD8 pos. tumor cells have been reported (not corresponding to the classical cases of pagetoid reticulosis; assignment to cytotoxic cutaneous T-cell lymphomas).
- Molecular biology: Detection of T-cell receptors of the alpha-beta or gamma-delta type.
Differential diagnosisThis section has been translated automatically.
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LiteratureThis section has been translated automatically.
- Kerscher M et al. Pagetoid reticulosis therapy with PUVA bath photochemotherapy. In: Plewig G et al (Ed.) Progress in practical dermatology and venereology 1995
- Luther H et al (1989) Pagetoid reticulosis of the type Ketron-Goodman. dermatologist 40: 530-535
- Matsuzaki Y et al (2009) Localized pagetoid reticulosis (Woringer-Kolopp disease) in early childhood. J Am Acad Dermatol 61:120-123
Mendese GW et al (2012) Pagetoid reticulosis in a prepubescent boy successfully treated with photodynamic therapy. Clin Exp Dermatol 37:759-761
Miedler JD et al (2008) Pagetoid reticulosis in a 5-year-old boy. J Am Acad Dermatol 58:679-681
- Morariu SH et al (2014) Pagetoid reticulosis Woringer-Kolopp type, a particular variant of mycosis fungoides: a case report. Rome J Morphol Embryol 55:1469-1472
- Nakada T et al (2002) Disseminated pagetoid reticulosis (Ketron-Goodman disease): six-year follow-up. J Am Acad Dermatol 47(2 Suppl): S183-186
Su O et al (2014) Treatment of localized pagetoid reticulosis with imiquimod: a case report and literature review. J Eur Acad Dermatol Venereol doi: 10.1111/jdv.12718
Wang T et al (2014) Localized pagetoid reticulosis (Woringer-Kolopp disease) completely response to NB-UVB combined with IFN. Dermatol Ther 27:227-229
- Woringer F, Kolopp P (1939) Lésion érythemato-squameuse polycyclique de l'avant-bras évoluant depuis 6 ans chez un garçonnet de 13 ans. Histologiquement infiltrate intra-épidermique d'apparance tumorale. Ann Dermatol Syphilogr (Paris) 10: 945-958
Incoming links (7)Aggressive cytotoxic epidermotropic cd8-positive t-cell lymphoma; Erythema anulare centrifugum; Mycosis fungoides type pagetoid reticulosis; Reticulosis, epidermotropic; Woringer, frédéric; Woringer-kolopp disease; Woringer-kolopp, m.;
Outgoing links (13)Acanthosis; Aggressive cytotoxic epidermotropic cd8-positive t-cell lymphoma; Bowen's disease; Cutaneous t-cell lymphomas; Epidermotropy; Excision; Mycosis fungoides (overview); Paget's disease extramammary; Papillomatosis; Psoriasis vulgaris; ... Show all
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