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Synonym(s)
Lutzner cells
DefinitionThis section has been translated automatically.
Atypical lymphocytoid cells with T-cell markers.
OccurrenceThis section has been translated automatically.
Among others, it occurs in cutaneous T-cell lymphoma, mycosis fungoides, lupus erythematosus, lichen planus, psoriasis, unspecific chronic dermatitis and in arthritis with synovial secretion.
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HistologyThis section has been translated automatically.
- Cells with a large, indented core of 6-10 μm size.
- Electron microscopy: Cerebriform nucleus, glycogen granules in the cytoplasm.
- Blood smear: PAS positive.
- Immunohistology: CD158k is expressed relatively constantly on Sezary cells (important diagnostic crystium) and acts as a co-inhibitory receptor which increases resistance to activation-induced cell death (apoptosis). Antibodies against CD158k may represent a therapeutic option.
- CD164 and FCRL3 serve as further diagnostic markers.
Note(s)This section has been translated automatically.
CD26 is discussed as a specific marker for Sézary cells.
LiteratureThis section has been translated automatically.
- Fierro MT et al (2006) Expression pattern of chemokine receptors and chemokine release in inflammatory erythroderma and Sezary syndrome. Dermatology 213: 284-292
Prof. Dr. med. Peter Altmeyer