Nitrofurantoin
Definition
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Chemotherapy drug.
Half-life
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0,3–0,5 h
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Spectrum of action
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Citrobacter spp., Enterobacter spp., Enterococcus faecalis, E. coli, Klebsiella spp., Proteus spp., Providencia spp., Serratia spp., Staphylococcus spp.
Indication
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Treatment and prophylaxis of uncomplicated urinary tract infections.
Dosage and method of use
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4 times 0.05-0.15 g/day p.o.
Undesirable effects
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Nausea, vomiting, liver dysfunction, cholestasis, lung changes to pulmonary fibrosis, allergic reactions, BB changes, polyneuropathy, dizziness, headache.
Interactions
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Prevention of absorption by magnesium salts, delayed absorption by simultaneous food intake.
Contraindication
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Pregnancy, lactation, infants up to 3 months of age, oliguria, renal failure, hemolytic anemia, hepatitis, pulmonary fibrosis, polyneuritis, glucose-6-phosphate dehydrogenase deficiency, polyneuropathy.
Preparations
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furadantine, uro-tablines, nifurantine
Note(s)
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Induction of a sweet syndrome after ingestion of nitrofurantoin has been described.
Literature
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- Callen JP et al (2002) Neutrophilic dermatoses. Dermatol Clin 20: 409-441
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Prof. Dr. med. Peter Altmeyer