Neomycin

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Synonym(s)

Neomycin sulfate

Definition
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Indication
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Topical: Bacterial inflammation of the eye area, local therapy of infected wounds, eczema, nummular, superinfected dermatoses, pyoderma, contagious impetigo. Systemic: Coma hepaticum, preoperative intestinal decontamination.

Dosage and method of use
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  • Ointment: Apply several times a day to the affected skin areas.
  • Eye drops: Instill 1 trp. up to 6 times/day into the conjunctival sac.
  • Eye Ointment: Apply a small amount into the conjunctival sac 3-4 times/day.

Remember! In order to prevent the infection from flaring up, continue the treatment for several days after all signs of the disease have subsided.

  • Tbl.: Intestinal decontamination: 6 times/day 1 g p.o. (for 1- max. 3 days). For Coma hepaticum: 4-max. 12 g/day spread over 4-6 ED (therapy duration not longer than 7 days).

Standard concentration
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Eye drops/ointment: 0.05%.

Undesirable effects
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Oto-, neuro-, nephrotoxicity, BB changes, allergic skin reactions, contact dermatitis, discolorations.

Contraindication
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Hypersensitivity to aminoglycoside antibiotics.

Preparations
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Myacyne ointment, neomycin, jellin-neomycin (combination preparation with fluocinolone acetonide), Isopto Max (combination preparation with dexamethasone)

Note(s)
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Evaluation of neomycin sulphate with regard to the effect of an allergy on the reduction of earning capacity:
  • Neomycin sulfate is an aminoglycoside antibiotic.
  • Relevant occupational exposures: Occupationally acquired sensitization is extremely rare. Occupational exposure occurs in medical professions (e.g. local therapeutics), including veterinary medicine and laboratory work (e.g. cell cultures).
  • Effect of an allergy: "Low" due to the very low prevalence of neomycin sulphate as an occupational substance.

Caution! Think of the possibility of sensitisation by the therapy of occupational eczema ("indirect" occupational disease)! Neomycin preparations are sensitive to light.

Literature
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  1. Diepgen TL et al. (2005) Evidence-based assessment of the effect of type IV allergies in the reduction of earning capacity - assessment of occupational skin diseases. Dermatologist 56: 207-223

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Last updated on: 29.10.2020