Lymphocytic infiltration of the skin L98.8

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Synonym(s)

benign lymphocytic infiltration of the skin; Jessner`s lymphocytic infiltrate; Jessner's lymphocytic infiltration of the skin; Lymphocytic infiltration of the skin

History
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Jessner and Kanof, 1953

Definition
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clinical picture, the entity of which is increasingly disputed. The term, introduced at a meeting of the Bronx Dermatological Society some 50 years ago, was purely descriptive and did not claim to be an independent disease. Nevertheless, it subsequently spread in dermatological textbooks under the term "lymphocytic infiltration". Many authors assume that the term can be deleted without replacement; the diagnosed cases are probably cases of lupus erythematosus tumidus, lymphadenosis cutis benigna, polymorphic light dermatosis or lymphoma-like insect bite reactions.

Etiopathogenesis
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Unclear, entity disputed. There have been reports of drug or infectious (Borrelia, Leishmania) induction of symptoms (ACE inhibitors). Some authors classify these skin symptoms as a variant of lupuserythematosus (lupus erythematosus tumidus).

Manifestation
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No gender preference; adults under 50 years of age; familial occurrence has been reported several times.

Localization
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Mainly face: Forehead, cheeks; also neck and nape of neck.

Clinical features
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Solitary or multiple, symmetrically or asymmetrically located, symptomless (no itching, no pain), differently sized, usually sharply defined, reddish or brownish-red, pad-like raised, rough, roundish, oval or polygonal plaques. No scaling, incrustations. No ulceration of the surface. Scarless healing after weeks or months.

Histology
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S.u. differential diagnosis and the respective clinical pictures.

Differential diagnosis
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The following disease patterns are not "true differential diagnoses", but rather reliable final diagnoses that could be determined after the primary clinical diagnosis "lymphocytic infiltration of the skin".

Therapy
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See below the respective diagnoses.

Literature
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  1. Bahmer FA (1992) Therapy for lymphocytic infiltration. dermatologist 43: 663
  2. Morgan J et al (1990) Satisfactory resolution of Jessner's lymphocytic infiltration of the skin following treatment with etretinat. Br J Dermatol 122: 570
  3. Dippel E et al (2002) Familial lymphocytic infiltration of the skin: histochemical and molecular analysis in three brothers. Dermatology 204: 12-16
  4. Jessner M, Kanof NB (1953) Lymphocytic infiltration of the skin. 68: 447-449 Arch Dermatol 68: 447-449
  5. Schepis C et al (2004) ACE-inhibitor-induced drug eruption resembling lymphocytic infiltration (of Jessner-Kanof) and Lupus erythematosus tumidus. Dermatology 208: 354-355
  6. Steinmann A et al (1999) Palpable migratory acriform erythema and lymphocytic infiltration of the skin--different presentations of the same entity? dermatologist 50: 270-274
  7. Toonstra J et al (1989) Jessner's lymphocytic infiltration of the skin. Arch dermatol 125: 1525-1530
  8. Weyers W et al (1998) LE or not LE- that is the question: An unusual attempt to separate lymphocytic infiltration from the spectrum of discoid lupus erythematosus. At J Dermatopathol 20: 225-232
  9. Ziemer M et al (2009) Lymphocytic infiltration of the skin (Jessner-Kanof) but not reticular erythematous mucinosis occasionally represents clinical manifestations of Borrelia-associated pseudolymphoma. Br J Dermatol 161:583-590

Disclaimer

Please ask your physician for a reliable diagnosis. This website is only meant as a reference.

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Last updated on: 29.10.2020