HistoryThis section has been translated automatically.
DefinitionThis section has been translated automatically.
You might also be interested in
ClassificationThis section has been translated automatically.
S.u. Hodgkin's lymphoma
Occurrence/EpidemiologyThis section has been translated automatically.
EtiopathogenesisThis section has been translated automatically.
ManifestationThis section has been translated automatically.
Clinical featuresThis section has been translated automatically.
Specific skin lesions (0.5-3.5% of patients):
- Blurred, squamous or nodular infiltrates.
- Single, multiple, or papulo-nodular exanthema-impressing, brownish to livid-red, cutaneous-subcutaneous nodules.
- Tendency to ulceration: lymphogranulomatous ulcer, especially on the trunk, lower abdomen, inguinal and thigh regions, and head.
- Specific infiltrates in the lymphatic pharyngeal ring with tendency to ulceration.
Nonspecific skin lesions (in 30-50% of patients):
- Pruritus: Excruciating pruritus with scratching effects, impetiginization, eczematization and lichenification, erythroderma, blistering, which can hardly be influenced by medication,
- Chronic prurigo (old name: prurigo lymphogranulomatotica)
- Hyperpigmentation: Diffuse, morbus-Addison-like hyperpigmentation on skin and mucous membranes.
- Ichthyotic skin lesions
- Zoster generalisatus, pyoderma.
Autoimmune diseases and Hodgkin's lymphoma: Hodgkin's lymphoma is associated with various autoimmune diseases or diseases from the atopic form group (Landgren O et al 2006). These include:
- Ulcerative colitis
- Atopic diseases (atopic dermatitis, bronchial asthma - Rafiq M et al 2020).
- Rheumatoid arthritis
- Systemic lupus erythematosus (Rahman A et al. 2007).
- Immune thrombocytopenic purpura
- Paraneoplastic pemphigus (Wang N et al. 2015)
- Mucinous pemphigoid (Durmus Ö et al 2020).
General symptoms of Hodgkin's lymphoma:
- Initial symptoms are often lymph node enlargement, especially in the neck and axillae. Furthermore B symptoms: weight loss, night sweats.
- In about one third of patients, lymph node pain a few minutes after alcohol consumption, relapsing lymphogranulomatous fever (Pel-Ebstein fever) with recurrent character.
- In early stage: Few days of fever alternating with fever-free intervals. In the late stage: appearance of Pel-Ebstein fever with retroperitoneal lymphoma. For detailed clinic and diagnosis see below. Hodgkin's lymphoma.
LaboratoryThis section has been translated automatically.
HistologyThis section has been translated automatically.
Depending on the cell infiltrate, a distinction is made between 5 different forms (see also under Hodgkin's lymphoma):
- Diffuse lymphocytic and/or histiocytic form (approx. 5% of cases).
- Nodular lymphocytic and/or histiocytic form (approx. 80% of cases)
- Mixed cell form (approx. 10-15% of cases)
- Diffuse fibrosis (approx. 1% of cases)
- Lymphocyte-poor form (approx. 1% of cases)
In the early phase, reticulum cell proliferations are seen in the lymph nodes, then an interspersion with neutrophil and eosinophil granulocytes, scarring, mononuclear (Hodgkin cells) and multinucleated (Sternberg-Reed giant cells), and atypical reticular cells. Skin biopsies are often less characteristic. Hodgkin and Sternberg-Reed cells are CD30/MIB1 positive.
An assignment of the specific skin infiltrates to the individual Hodgkin subtypes has not yet been made.
DiagnosisThis section has been translated automatically.
Differential diagnosisThis section has been translated automatically.
TherapyThis section has been translated automatically.
Polychemotherapy or radiotherapy by haematologists or radiotherapists. For further details see below. Hodgkin's lymphoma.
Progression/forecastThis section has been translated automatically.
LiteratureThis section has been translated automatically.
- Ambinder R (2003) Infection and lymphoma. N Engl J Med 349: 1309-1311
- Browne P et al (2003) The B-cell transcription factors BSAP, Oct-2, and BOB.1 and the pan-B-cell markers CD20, CD22, and CD79a are useful in the differential diagnosis of classic Hodgkin lymphoma. Am J Clin Pathol 120: 767-777
- Durmus Ö et al (2020) Mucous membrane pemphigoid in a patient treated with nivolumab for Hodgkin's lymphoma. Dermatol Ther 33:e14109.
- Hjalgrim H et al (2003) Characteristics of Hodgkin's lymphoma after infectious mononucleosis. N Engl J Med 349: 1324-1332
- Hodgkin T (1832) On some morbid appearances of the absorbent glands and spleen. Medico-Chirurgical Transactions (London) 17: 68-114
- Khalifeh I et al. (2009) Solitary plaque on the scalp as a primary manifestation of Hodgkin lymphoma: a case report and review of the literature. J Cutan Pathol 36 Suppl 1:80-85.
- Landgren O et al (2006) Autoimmunity and susceptibility to Hodgkin lymphoma: a population-based case-control study in Scandinavia. J Natl Cancer Inst 98:1321-1330.
- Listinsky CM et al (2002) A practical approach to the diagnosis of Hodgkin lymphoma. Am J Clin Pathol 117S: S76-94.
- Macaya A et al (2003) Cutaneous granulomas as the first manifestation of Hodgkin's disease. Eur J Dermatol 13: 299-301
- Paltauf R (1889) On the relations of the thymus to sudden death. Vienna Klin Wschr 46: 877-881
- Paltauf R (1897) Lymphosarcoma (lymphosarcomatosis, pseuloleukemia, myeloma, chloroma). Results of general pathology and pathological anatomy of man and animals 3: 652-691.
- Rahman A et al (2007) Hodgkin's lymphoma in systemic lupus erythematosus. Rheumatology (Oxford) 46:830-832.
- Rafiq M et al (2020) Allergic disease, corticosteroid use, and risk of Hodgkin lymphoma: A United Kingdom nationwide case-control study. J Allergy Clin Immunol 145:868-876.
- Reed D (1902) On the pathological changes in Hodgkin's disease, with especial reference to its relation to tuberculosis. Johns Hopkins Hospital Reports (Baltimore) 10: 133-196.
- Serra-García L et al (2021) Chronic prurigo as an onset of Hodgkin's lymphoma. Med Clin (Barc) 156:47.
- Sternberg C (1898) Ueber eine eigenartige, unter dem Bild der Pseudoleukämie verlaufende Tuberkulose des lymphatischen Apparates. Journal of Medical Science (Prague) 19: 21-90.
- Wang N et al (2015) Paraneoplastic pemphigus as the first manifestation of non-Hodgkin's lymphoma: a case report and literatures review. Zhonghua Xue Ye Xue Za Zhi 36:702-.
- Winzer M, Müller W, Arnholdt H (1991) Specific skin infiltrates in Hodgkin's disease. Dermatologist 42: 648-651
Incoming links (17)Brentuximab vedotine; Hodgkin, m.; Hodgkin's disease; Hodgkin's sarcoma; Ichthyosis, paraneoplastic; Lymphadenopathy, dermatopathic; Lymphogranuloma papulosum disseminatum; Lymphogranulomatosis maligna; Lymphogranulomatous ulcer; Lymphomatoids papulose; ... Show all
Outgoing links (17)Atopy; Cd30; Chronic prurigo; Cutaneous non hodgkin lymphomas; Cutaneous t-cell lymphomas; Erythroderma; Hodgkin's lymphoma; Lichenification; Lupus erythematosus systemic; Mucous membrane pemphigoid; ... Show all
Please ask your physician for a reliable diagnosis. This website is only meant as a reference.