Glove-sock syndrome R21

Author: Prof. Dr. med. Peter Altmeyer

Our authors

Last updated on: 29.10.2020

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Synonym(s)

Papular purple gloves and socks syndrome; PPGSS

History
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Harms, 1990

Definition
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Polyätiological, acral accentuated exanthema, which occurs associatively to viral infections.

Etiopathogenesis
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Associative exanthema in various viral diseases: parvovirus B19 is the main associated disease, hepatitis B, cytomegaly, Coxsackie B6, measles, rubella, HHV-6, HHV-7 more rarely, PPGSS is also associated with drugs(trimethoprim/sulfmethoxazole).

Localization
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Hands and feet.

Clinical features
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Acral accentuated exanthema of itchy, 2-4 mm large, isolated or even confluent red spots. The exanthema may be associated with fever, lymph node swelling and arthralgia.

Laboratory
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Non-specific.

Diagnosis
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Clinical picture; clarification of an associated viral disease.

Differential diagnosis
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Therapy
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Symptomatic.

Literature
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  1. Alfadley A et al (2003) Papular-purpuric "gloves and socks" syndrome in a mother and daughter. J Am Acad Dermatol 48: 941-944
  2. Eijnden SV et al (2003) Gloves and socks lymphangitis associated with acute parvovirus B19 infection. Pediatric dermatol 20: 184-186
  3. Ghigliotti G et al (2000) Papular-purpuric gloves and socks syndrome in HIV-positive patients. J Am Acad Dermatol 43: 916-917
  4. Grilli R et al (1999) Papular-purpuric "gloves and socks" syndrome: polymerase chain reaction demonstration of parvovirus B19 DNA in cutaneous lesions and sera. J Am Acad Dermatol 41: 793-796
  5. Harms M et al (1990) Papular-purpuric "gloves and socks" syndrome. J Am Acad Dermatol 23: 850-854
  6. Smith SB et al (2002) Gloves and socks syndrome: early and late histopathologic features. J Am Acad Dermatol 47: 749-754
  7. Segui N et al (2000) Papular-purpuric 'Gloves-and-Socks' syndrome related to rubella virus infection. Dermatology 200: 89
  8. Tonelli S et al (2002) "Gloves and socks" papular purpuric syndrome following primary infection with parvovirus B19: a link between dermatologists and haematologists. Br J Haematol 117: 773-774

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Please ask your physician for a reliable diagnosis. This website is only meant as a reference.

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Last updated on: 29.10.2020