Ergotism T46.5

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Synonym(s)

Saint Anthony's fire

Definition
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Arterial vasospastic circulatory disorders as a result of chronic poisoning with substances containing ergotamine (migraine medication). The poisoning by alkaloids of ergot, which used to lead to mass diseases, is extremely rare today (see Lolch.

Manifestation
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The arteries of the extremities (e.g. digital arteries) are particularly affected.

Clinical features
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Clinically, the symptoms of an arterial circulatory disorder and neurological symptoms such as cramps or contractures are evident.

General therapy
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Stop taking medication containing ergotamine. Cooperation with neurologists and internists.

External therapy
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Symptomatic stage-appropriate therapy of the skin changes. See also wound treatment.

Internal therapy
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In severe cases, attempt vasodilatory acute medication, e.g. with calcium antagonists such as nifedipine (e.g. Adalat) 0.1-0.2 mg i.v. or 10 mg sublingual or glycerol nitrate (e.g. Nitrolingual spray).In case of superinfection initial broad-spectrum antibiotics e.g. with cephalosporins such as cefotaxime (e.g. claforan 2 times 2 g/day i.v.) or gyrase inhibitors such as ciprofloxacin (e.g. Ciprobay 250-500 mg/day p.o.). As soon as possible antibiotic therapy after antibiogram.

Disclaimer

Please ask your physician for a reliable diagnosis. This website is only meant as a reference.

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Last updated on: 29.10.2020