HistoryThis section has been translated automatically.
The designation "epidermal nevus" as hamartoma of the skin, refers to v. Baerensprung, who first used the designation "Naevus unius lateris" (cited in Su et al.) for a systematized verrucous nevus in 1863.
DefinitionThis section has been translated automatically.
Inflammatory or non-inflammatory, reddish-brownish or dirty-brownish, soft-papillomatous or wart-like-hard malformations of the epidermis (often with a dermal component), which are congenital or appear in the first years of life and can be interpreted as a cutaneous mosaic, and which, apart from the CHILD syndrome, manifest themselves in the Blaschko lines or as other cutaneous mosaics.
Various epidermal nevi are to be considered as monitoring signs of complex syndromal malformations.
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ClassificationThis section has been translated automatically.
The following distinctions can be made:
- Simple (non-organoid) epidermal nevi (affecting only the epidermis).
- compound "organoid" epidermal nevi (involving epidermis and skin appendages)
- Epidermal nevi as monitorial signs for syndromes.
- Epidermal nevi:
- Papillomatous (soft) epidermal nevus (postzygotic mutations in the genes FGFR3,PIK3CA, KRAS)
- Verrucous (hard) epidermal nevus ( nevus verrucosus
)Special form: nevus
verrucosus unius lateralis
- Epidermolytic epidermal nevus (minus variant of keratosis plamoplantaris diffusa with mutations in keratin1)
- CHILD syndrome
- Corniculatus nevus
- Segmental M. Darier
- Segmental Hailey-Hailey disease ( pemphigus chronicus benignus familiaris)
- Linear porokeratosis (linear manifestation of disseminated superficial actinic porokeratosis)
- Linear manifestation of plaque-like porokeratosis mibelli
- Organoid (compound) epidermal nevi:
- Epidermal nevi as monitoring signs for syndromes
- Epidermal nevi:
Occurrence/EpidemiologyThis section has been translated automatically.
The incidence is estimated at 1:1000 children. In a larger study with 131 nevi occurring up to 14 years of age, 80% of the nevi were present at birth (Rogers M et al. 1989).
HistologyThis section has been translated automatically.
From a histopathological point of view (cited in Su 1982) the following classification results:
- acrokeratosis verruciformis-like
- Seborrheic keratosis-like
- Psoriasiform (eczematoid) - inflammatory linear verrucous epidermal nevus = ILVEN
- Wart-like (verrucous)
LiteratureThis section has been translated automatically.
- The A et al (2014) Linear non-epidermolytic verrucous epidermal nevus. Indian Pediatr 51:591
- Fan YM et al (2014) An atypical variant of phacomatosis pigmentokeratotica: verrucous epidermal nevus, speckled lentiginous nevus, and pointed nevus associated with scoliosis. Int J Dermatol 53: 619-621
- Kruse LL et al (2015) Differential Diagnosis of Linear Eruptions in Children. Pediatr Ann.44:e194-e198
- Su WP(1082)Histopathological varieties of epidermal nevus. A study of 160 cases. At J Dermatopathol 4:161-170
- Rogers M et al (1989) Epidermal nevi and the epidermal nevus syndrome.
A review of 131 cases. J Am Acad Dermatol 20:476-88.
- Waghmare RS et al. (2013) Inflammatory linear verrucous epidermal nevus. J Assoc Physicians India 61:431-432
Incoming links (12)Angiokeratomas, acral pseudolymphomatous childhood; Clove syndrome; Comedonic nevus; Cornicardial nevus; Curly hair nevus; Erbium yag laser; FGFR3; Hypermelanosis nevoid, striped and vertebral; Linear proteus nevus; Naevus, papillomatous, soft epidermal; ... Show all
Outgoing links (27)Becker-naevus syndrome; Becker's nevus; Blaschko lines; Child syndrome; Comedonic nevus; Cornicardial nevus; Curly hair nevus; Dyskeratosis follicularis; FGFR3; Haarnaevus; ... Show all
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