Porokeratotic eccrine ostiumnaevus D22.9

Rare hamartoma with eccrine differentiation (see also Hamartoma, eccrine), which clinically resembles comedone nevus, but occurs preferentially on the palms and soles, where pilosebaceous follicles are absent. It is a cornification disorder involving the intraepidermal ductus eccrinus (acrosyringium), characterized in pathology by an eccrine hamartoma and a cornoid lamella.

If necessary, excision. Otherwise conservative care.

The 29-year-old patient noticed pruritic skin lesions on the right lateral malleolus for 8 years. Pathological examination revealed multiple small epidermal invaginations with overlying parakeratotic cornoid lamellation, loss of granular layer, and few dyskeratotic cells at the base of the epidermal invagination. After clinicopathologic correlation, a diagnosis of porokeratotic eccrine ostial and dermal duct nevus (PEODDN) was made (see Fig.).

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