Chlorhexidine

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Synonym(s)

Chlorhexidine gluconate; INCI designation: Chlorhexidine gluconates

Definition
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Pharmacodynamics (Effect)
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Broad antimicrobial effect against various gram-positive and gram-negative bacteria. Low effective against some gram negative bacteria (Pseudomonas spp. and Proteus spp.), yeasts, dermatophytes and mycobacteria. Ineffective against bacterial and fungal spores, viruses and putrefactive fungi.

Indication
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Inflammation of the mouth and throat mucosa. Antiseptic treatment of superficial abrasions, lacerations, lacerations and scratches. First degree burns.

Undesirable effects
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Contact dermatitis, swelling of the salivary glands, immediate anaphylactoid contractions. The exact prevalence of chlorhexidine allergies is unknown (Sustal K et al. 2017). Due to the widespread and increasing use of chlorhexidine, an increasing rate of sensitization is expected. This also concerns IgE-mediated immediate reactions (detectable by prick testing).

Notice! With oral application: discoloration of tongue and teeth is possible! Do not use together with toothpaste.

Interactions
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Interactions with anionic surfactants (e.g. contained in toothpaste) and soaps.

Preparations
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Bactigras, Chlorhexamed, Chlorhexidingluconate Lsg., Cidegol C, Frubilurgyl, Hansamed Spray, Lemocin CX, Bepanthen Antiseptic wound cream (combined preparation with dexpanthenol).

Literature
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  1. Ammann PM et al (2018) Disinfectants. Allergo J 27:16-18
  2. Sustal K et al (2017) Chlorhexidine allergy-underestimated allergen with ubiquitous use. Allergo J Int 26: 69-70

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Last updated on: 29.10.2020