Cd11a

Markers for: B cells, T cells, monocytes, activated platelets, granulocytes, macrophages

Structure: Transmembrane glycoprotein (170 kDa)

Note: Belongs to the integrins associated with a subunit of CD18; LFA-1 (CD11a/CD18) promotes the adhesion of leukocytes to the vascular endothelium. Important ligands of LFA-1 are the intercellular adhesion molecules (ICAMs)

Application: FACS, IHC (P) (G), IF

(see below) Cluster of differentiation

Antibodies against LF-1 were used for the therapy of psoriasis with moderate success. In this type of treatment, a possible association with the development of progressive multifocal leukoencephalopathy (PML) has been identified. The drug was withdrawn from the market.

1. Hantschke M et al (2016) Immunohistological techniques. In: L. Cerroni et al. histopathology of the skin. Springer publishing house Berlin-Heidelberg p. 26-33.