ITGAX gene

The ITGAX gene (ITGAX stands for: integrin subunit alpha X) is a protein-coding gene located on chromosome 16p11.2. Two transcript variants have been found for this gene, which code for different isoforms. The associated signaling pathways include apoptotic signaling pathways in synovial fibroblasts and the integrin signaling pathway. Gene ontology (GO) describes the activity of signaling receptors . An important paralog of this gene is ITGAD .

The ITGAX gene codes for the integrin αX chain protein. Integrin αX/β2 is a receptor for fibrinogen. The encoded protein combines with the β2 chain (ITGB2) to form a leukocyte-specific integrin, the inactivated C3b receptor 4 (iC3b receptor 4, CR4), which is also known as CD11c (see also CD11a and CD11b). The αXβ2 complex appears to have similar properties to the αMβ2 integrin in the adhesion of neutrophils and monocytes to stimulated endothelial cells and in the phagocytosis of complement-coated particles. The receptor protein αX/β2 mediates cell-cell interaction during inflammatory reactions. It is also important for cell adhesion and chemotaxis in immune cells such as monocytes, granulocytes and dendritic cells.

1. Ni L et al. (2023) SERPINB8 and furin regulate ITGAX expression and affect the proliferation and invasion of melanoma cells. Exp Dermatol 32:24-29.
2. Zhang Y et al. (2024) A basement membrane-related signature for prognosis and immunotherapy benefit in bladder cancer based on machine learning. Discov Oncol 15:537.
3. Zhang W et al. (2024) Machine learning developed an intratumor heterogeneity signature for predicting prognosis and immunotherapy benefits in skin cutaneous melanoma. Melanoma Res 34:215-224.