Cannabinoids

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Definition
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Substances secreted by the hemp plant (cannabis) as resin on the surface of the leaves.

General information
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  • A sticky, resinous film is secreted on the surface of the plant. This film has an antimicrobial effect and offers the plant protection against micro-organisms (bacteria and fungi). There are both natural and synthetic cannabinoids. Important natural cannabinoids are e.g. Delta-9-tetrahydrocannabinol (THC) and its antagonist cannabidiol (CBD).
  • The target structures of cannabinoids upon uptake into the human organism are the cannabinoid receptors CB1 and CB2. The receptors bind N-palmitoylethanolamine ( PEA) and mediate analgesic, sedative and antiemetic effects. Nabilone, a synthetic cannabinoid, is used as an antiemetic in oncology. Only recently the expression of cannabinoid receptors in human skin has been described. This knowledge has already been used in studies for the treatment of chronic pruritus (available preparation = Physiogel AI cream).

Note(s)
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Cannabinoids are on the doping list!

Literature
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  1. Ständer S et al (2005) Distribution of cannabinoid receptor 1 (CB1) and 2 (CB2) on sensory nerve fibers and adnexal structures in human skin. J Dermatol Sci 38: 177-188

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Last updated on: 29.10.2020