Cannabinoid receptors

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Definition
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Receptors coupled to a G-protein that are activated by cannabinoids.

General information
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Currently, two cannabinoid receptors have been described (CB1 and CB2 receptors) that modulate ion channels and signaling pathways. Cannabinoid receptors bind N-palmitoylethanolamine ( PEA) and induce sedative, antiemetic and analgesic effects in the central nervous system. The occurrence of the CB1-receptor was previously only known in the central nervous system, CB2-receptors are found in peripheral blood cells and in the tissue of the immune system. In the meantime, both receptors have been detected in the skin. Of interest is the expression of both receptors on mast cells and unmyelinated C nerve fibres, which play a role in the development of pruritus. For the treatment of chronic pruritus, cannabinoid agonists were topically applied in a study. These are believed to have a mast cell-stabilizing function, which consecutively inhibits the histamine release responsible for itching.

Literature
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  1. Stand S et al (2006) Topical cannabinoid agonists. An effective new possibility for treating chronic pruritus. dermatologist 57: 801-807

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Last updated on: 29.10.2020