GPR55-receptor

The GPR55 receptor is a receptor protein that belongs to the superfamily of G protein-coupled receptors. The coding gene of the same name is located on chromosome 2q37.1.

GPR55 transcripts are detected mainly in neurons in brain nuclei associated with movement control: striatum, globus pallidus, nucleus subthalamicus, substantia nigra and cortex (Celorrio M et al. 2017). Furthermore, in monocytes and in cells of microglia. GPR55 modulates inflammatory processes (Saliba SW et al 2018).

Abn-cannabidiol (Abn-CBD), a synthetic cannabidiol (CBD) isomer, is a GPR55 agonist. Activation of GPR55 may be beneficial in the treatment of PD (Celorrio M et al. 2017).

1. Cho YJ et al (2020) Ginseng Gintonin Contains Ligands for GPR40 and GPR55. Molecules 25:1102
2. Celorrio M et al (2017) GPR55: A therapeutic target for Parkinson's disease? Neuropharmacology 125:319-332.
3. Saliba SW et al. (2018) Anti-neuroinflammatory effects of GPR55 antagonists in LPS-activated primary microglial cells. J Neuroinflammation 15:322.