DefinitionThis section has been translated automatically.
Complete or partial, acquired or congenital "naillessness" on fingers and/or toes
EtiopathogenesisThis section has been translated automatically.
- Traumatically induced
- unguinea unguium
- lichen planus
- Chronic eczema diseases
- psoriasis vulgaris
- Acrodermatitis continua suppurativa
- Erythroderma of different genesis
- Medically acquired with prenatal phenytoin intake.
Congenital Anonychia: A number of different syndromes have been described:
- Anonychia congenita: In autosomal recessive congenital anonychia (OMIM 206800) the leading symptom is the already congenitally appearing anoynchia (no hypoplasia of the bony end phalanges). Mutations in the RSPO4 gene, which codes for R-spondin 4, a component of the Wnt signalling pathway, have been demonstrated.
- In the mamma-fingernail syndrome the nails are missing in hypoplasia or complete absence of the end phalanges.
- In Cooks syndrome, nail dystrophy progresses to ring and little finger anonymity and thumb digitalization.
- In the Anonychia Electrodactylya syndrome, the finger anomalies are asymmetrical, including the absence of 1 or more fingers.
- 20-nail dystrophy
- Nail-patella syndrome (Anonychia, hyponychia, onychoschisis, triangular lunula. Affected are mainly thumb and index finger nails; toenails are almost always normal).
- Isolated onycholysis of ononychia (nail disorder, nonsyndromic congenital 9: this is an autosomal recessive inherited nail dystrophy. The nails appear normal at birth; in the first decade of life onycholysis of the toenails leading to anonychia)
TherapyThis section has been translated automatically.
In the case of acquired anonymity: treatment of the underlying disease, see there.
LiteratureThis section has been translated automatically.
- Afsar FS et al (2014) Total congenital anonychia. Pediatric dermatol 31:743-744
- Babu S et al (2012) Anonychia due to prenatal phenytoin exposure. J Assoc Physicians India 60:64
- Balta I et al (2013) A case report on autosomal recessive total congenital anonychia. Pediatric Dermatol 30: e268-269
- de Lau WB et al (2012) The R-spondin protein family. Genomes Biol.13:242
- Lam C et al (2013) Images in clinical medicine. Epidermolysis bullosa acquisita. N Engl J Med 368:e17
- Khan TN et al (2012) Novel missense mutation in the RSPO4 gene in congenital hyponychia and evidence for a polymorphic initiation codon (p.M1I). BMC Med gene 13:120
Incoming links (13)Acrodermatitis continua suppurativa; Anonychie acquired; Anonychosis; Dorsal pterygium; Dyskeratosis congenita; Dysplasia, chondroectodermal; Dysplasia ectodermal; Hay-wells syndrome; Isolated anonychy-onycholysis; Nail diseases with genodermatoses; ... Show all
Outgoing links (14)Acrodermatitis continua suppurativa; Anonychia-electrodactyly syndrome; Congenital anonychia; Cooks syndrome; Eczema (overview); Erythroderma; exfoliative dermatitis;; Isolated anonychy-onycholysis; Lichen planus (overview); Nail-patella syndrome; Onychomycosis (overview); ... Show all
Please ask your physician for a reliable diagnosis. This website is only meant as a reference.